PPP5C

Protein phosphatase 5, catalytic subunit

PDB rendering based on 1a17.

Available structures
PDB	1A17, 1S95, 1WAO, 2BUG, 3H60, 3H61, 3H62, 3H63, 3H64, 3H66, 3H67, 3H68, 3H69

Identifiers

Symbols

PPP5C; FLJ36922; FLJ55954; PP5; PPP5; PPT

External IDs

OMIM: 600658 MGI: 102666 HomoloGene: 4550 GeneCards: PPP5C Gene

EC number

3.1.3.16

Gene Ontology
Molecular function	• protein serine/threonine phosphatase activity • signal transducer activity • protein binding • hydrolase activity • metal ion binding
Cellular component	• nucleus • cytoplasm • Golgi apparatus • cytosol • neuron projection • neuronal cell body
Biological process	• transcription, DNA-dependent • protein dephosphorylation • mitosis • signal transduction • positive regulation of I-kappaB kinase/NF-kappaB cascade • response to morphine • protein heterooligomerization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
46.85 – 46.9 Mb

Chr 7:
17.59 – 17.61 Mb

PubMed search

[1]

[2]

Serine/threonine-protein phosphatase 5 is an enzyme that in humans is encoded by the PPP5C gene.^[1]^[2]

Interactions

PPP5C has been shown to interact with ASK1,^[3] CRY2^[4] GNA12.^[5] and Rac1,^[6]

References

^ Yong WH, Ueki K, Chou D, Reeves SA, von Deimling A, Gusella JF, Mohrenweiser HW, Buckler AJ, Louis DN (Aug 1996). "Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region on chromosome 19q13.3". Genomics 29 (2): 533–6. doi:10.1006/geno.1995.9972. PMID 8666404.
^ "Entrez Gene: PPP5C Protein phosphatase 5, catalytic subunit". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5536.
^ Morita, K; Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H (Nov. 2001). "Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress". EMBO J. (England) 20 (21): 6028–36. doi:10.1093/emboj/20.21.6028. ISSN 0261-4189. PMC 125685. PMID 11689443. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125685.
^ Zhao, S; Sancar A (Nov. 1997). "Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity". Photochem. Photobiol. (UNITED STATES) 66 (5): 727–31. doi:10.1111/j.1751-1097.1997.tb03214.x. ISSN 0031-8655. PMID 9383998.
^ Yamaguchi, Yoshiaki; Katoh Hironori, Mori Kazutoshi, Negishi Manabu (Aug. 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Curr. Biol. (England) 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. ISSN 0960-9822. PMID 12176367.
^ Chatterjee, A; Wang L, Armstrong DL, Rossie S (Feb. 2010). "Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro". J. Biol. Chem. 285 (6): 3872–82. doi:10.1074/jbc.M109.088427. PMC 2823530. PMID 19948726. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2823530.

Chen MX, McPartlin AE, Brown L, et al. (1994). "A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus.". EMBO J. 13 (18): 4278–90. PMC 395355. PMID 7925273. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=395355.
Skinner J, Sinclair C, Romeo C, Armstrong D, Charbonneau H, Rossie S (1997). "Purification of a fatty acid-stimulated protein-serine/threonine phosphatase from bovine brain and its identification as a homolog of protein phosphatase 5.". J. Biol. Chem. 272 (36): 22464–71. doi:10.1074/jbc.272.36.22464. PMID 9278397.
Shah BH, Catt KJ (2007). "Protein phosphatase 5 as a negative key regulator of Raf-1 activation.". Trends Endocrinol. Metab. 17 (10): 382–4. doi:10.1016/j.tem.2006.10.013. PMID 17084641.
Goedert M, Cohen ES, Jakes R, Cohen P (1992). "p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]". FEBS Lett. 312 (1): 95–9. doi:10.1016/0014-5793(92)81418-L. PMID 1330687.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Xu X, Lagercrantz J, Zickert P, et al. (1996). "Chromosomal localization and 5' sequence of the human protein serine/threonine phosphatase 5' gene.". Biochem. Biophys. Res. Commun. 218 (2): 514–7. doi:10.1006/bbrc.1996.0092. PMID 8561788.
Silverstein AM, Galigniana MD, Chen MS, et al. (1997). "Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin.". J. Biol. Chem. 272 (26): 16224–30. doi:10.1074/jbc.272.26.16224. PMID 9195923.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhao S, Sancar A (1998). "Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity.". Photochem. Photobiol. 66 (5): 727–31. doi:10.1111/j.1751-1097.1997.tb03214.x. PMID 9383998.
Ollendorff V, Donoghue DJ (1998). "The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex.". J. Biol. Chem. 272 (51): 32011–8. doi:10.1074/jbc.272.51.32011. PMID 9405394.
Das AK, Cohen PW, Barford D (1998). "The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions.". EMBO J. 17 (5): 1192–9. doi:10.1093/emboj/17.5.1192. PMC 1170467. PMID 9482716. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170467.
Russell LC, Whitt SR, Chen MS, Chinkers M (1999). "Identification of conserved residues required for the binding of a tetratricopeptide repeat domain to heat shock protein 90.". J. Biol. Chem. 274 (29): 20060–3. doi:10.1074/jbc.274.29.20060. PMID 10400612.
Lubert EJ, Hong Y, Sarge KD (2001). "Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5.". J. Biol. Chem. 276 (42): 38582–7. doi:10.1074/jbc.M106906200. PMID 11504734.
Morita K, Saitoh M, Tobiume K, et al. (2001). "Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.". EMBO J. 20 (21): 6028–36. doi:10.1093/emboj/20.21.6028. PMC 125685. PMID 11689443. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125685.
Sanchez-Ortiz E, Hahm BK, Armstrong DL, Rossie S (2009). "Protein phosphatase 5 protects neurons against amyloid-beta toxicity.". J. Neurochem. 111 (2): 391–402. doi:10.1111/j.1471-4159.2009.06337.x. PMID 19686245.
Yamaguchi Y, Katoh H, Mori K, Negishi M (2003). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity.". Curr. Biol. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367.
Gentile S, Darden T, Erxleben C, Romeo C, Russo A, Martin N, Rossie S, Armstrong DL (2006). "Rac GTPase signaling through the PP5 protein phosphatase.". Proc. Natl. Acad. Sci. USA 103 (13): 5202–6. doi:10.1073/pnas.0600080103. PMID 16549782.
Liu F, Zaidi T, Iqbal K, et al. (2003). "Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.". Neuroscience 115 (3): 829–37. doi:10.1016/S0306-4522(02)00510-9. PMID 12435421.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Urban G, Golden T, Aragon IV, et al. (2003). "Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression.". J. Biol. Chem. 278 (11): 9747–53. doi:10.1074/jbc.M210993200. PMID 12519780.
Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.". J. Biol. Chem. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.

PDB gallery

1a17: TETRATRICOPEPTIDE REPEATS OF PROTEIN PHOSPHATASE 5

1s95: Structure of serine/threonine protein phosphatase 5

1wao: PP5 STRUCTURE

2bug: SOLUTION STRUCTURE OF THE TPR DOMAIN FROM PROTEIN PHOSPHATASE 5 IN COMPLEX WITH HSP90 DERIVED PEPTIDE

PPP5C

Interactions

References

Further reading