PPP3CC

Protein phosphatase 3, catalytic subunit, gamma isozyme

Identifiers

PPP3CC; CALNA3; CNA3; PP2Bgamma

External IDs

OMIM: 114107 MGI: 107162 HomoloGene: 68475 GeneCards: PPP3CC Gene

3.1.3.16

Gene Ontology
Molecular function	• phosphoprotein phosphatase activity • calmodulin binding • hydrolase activity • metal ion binding
Cellular component	• cytosol • cytosol
Biological process	• apoptosis • induction of apoptosis by intracellular signals • activation of pro-apoptotic gene products • activation of pro-apoptotic gene products
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
22.3 – 22.4 Mb

Chr 14:
70.62 – 70.69 Mb

PubMed search

[1]

[2]

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PPP3CC gene.^[1]^[2]

Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).[supplied by OMIM]^[2]

References

^ Muramatsu T, Kincaid RL (Nov 1992). "Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)". Biochem Biophys Res Commun 188 (1): 265–71. doi:10.1016/0006-291X(92)92379-C. PMID 1339277.
^ ^a ^b "Entrez Gene: PPP3CC protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5533.

Esau C, Boes M, Youn HD et al. (2001). "Deletion of Calcineurin and Myocyte Enhancer Factor 2 (MEF2) Binding Domain of Cabin1 Results in Enhanced Cytokine Gene Expression in T Cells". J. Exp. Med. 194 (10): 1449–59. doi:10.1084/jem.194.10.1449. PMC 2193671. PMID 11714752. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193671.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
Gerber DJ, Hall D, Miyakawa T et al. (2003). "Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 8993–8. doi:10.1073/pnas.1432927100. PMC 166426. PMID 12851458. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=166426.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Barrios-Rodiles M, Brown KR, Ozdamar B et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Eastwood SL, Burnet PW, Harrison PJ (2005). "Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia". Biol. Psychiatry 57 (7): 702–10. doi:10.1016/j.biopsych.2004.12.029. PMID 15820226.
Kinoshita Y, Suzuki T, Ikeda M et al. (2006). "No association with the calcineurin A gamma subunit gene (PPP3CC) haplotype to Japanese schizophrenia". Journal of neural transmission (Vienna, Austria : 1996) 112 (9): 1255–62. doi:10.1007/s00702-004-0261-5. PMID 15843870.
Liu YL, Fann CS, Liu CM et al. (2008). "More evidence supports the association of PPP3CC with schizophrenia". Mol. Psychiatry 12 (10): 966–74. doi:10.1038/sj.mp.4001977. PMID 17339875.
Horiuchi Y, Ishiguro H, Koga M et al. (2008). "Support for association of the PPP3CC gene with schizophrenia". Mol. Psychiatry 12 (10): 891–3. doi:10.1038/sj.mp.4002019. PMID 17895921.

PPP3CC

References

Further reading