PPP2R2A

Protein phosphatase 2, regulatory subunit B, alpha

Identifiers

PPP2R2A; B55A; B55ALPHA; DKFZp686N05117; FLJ26613; FLJ41727; MGC52248; PR52A; PR55A

External IDs

OMIM: 604941 MGI: 1919228 HomoloGene: 2035 GeneCards: PPP2R2A Gene

3.1.3.16

Gene Ontology
Molecular function	• protein serine/threonine phosphatase activity • protein binding • protein phosphatase type 2A regulator activity
Cellular component	• protein phosphatase type 2A complex
Biological process	• protein dephosphorylation • signal transduction • response to morphine
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
26.15 – 26.23 Mb

Chr 14:
67.63 – 67.69 Mb

PubMed search

[1]

[2]

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform is an enzyme that in humans is encoded by the PPP2R2A gene.^[1]

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily.^[2]

Interactions

PPP2R2A has been shown to interact with PPP2R1B,^[3]^[4] PPP2R1A,^[4]^[5] TGF beta receptor 1,^[6] P70-S6 Kinase 1^[7]^[8] and PPP2CA.^[3]^[5]

References

^ Mayer RE, Hendrix P, Cron P, Matthies R, Stone SR, Goris J, Merlevede W, Hofsteenge J, Hemmings BA (May 1991). "Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform". Biochemistry 30 (15): 3589–97. doi:10.1021/bi00229a001. PMID 1849734.
^ "Entrez Gene: PPP2R2A protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5520.
^ ^a ^b Kamibayashi, C; Lickteig R L, Estes R, Walter G, Mumby M C (October 1992). "Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits". J. Biol. Chem. (UNITED STATES) 267 (30): 21864–72. ISSN 0021-9258. PMID 1328247.
^ ^a ^b Zhou, Jin; Pham Huong T, Ruediger Ralf, Walter Gernot (January 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". Biochem. J. (England) 369 (Pt 2): 387–98. doi:10.1042/BJ20021244. ISSN 0264-6021. PMC 1223084. PMID 12370081. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223084.
^ ^a ^b Goudreault, Marilyn; D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics (United States) 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2621004.
^ Griswold-Prenner, I; Kamibayashi C, Maruoka E M, Mumby M C, Derynck R (November 1998). "Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A". Mol. Cell. Biol. (UNITED STATES) 18 (11): 6595–604. ISSN 0270-7306. PMC 109244. PMID 9774674. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109244.
^ Peterson, R T; Desai B N, Hardwick J S, Schreiber S L (April 1999). "Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (8): 4438–42. doi:10.1073/pnas.96.8.4438. ISSN 0027-8424. PMC 16350. PMID 10200280. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16350.
^ Bishop, Jessica D; Nien Wei Lun, Dauphinee Shauna M, Too Catherine K L (August 2006). "Prolactin activates mammalian target-of-rapamycin through phosphatidylinositol 3-kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 in lymphoma cells". J. Endocrinol. (England) 190 (2): 307–12. doi:10.1677/joe.1.06368. ISSN 0022-0795. PMID 16899564.

Zolnierowicz S (2000). "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways.". Biochem. Pharmacol. 60 (8): 1225–35. doi:10.1016/S0006-2952(00)00424-X. PMID 11007961.
Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
Andersen JL, Planelles V (2005). "The role of Vpr in HIV-1 pathogenesis.". Curr. HIV Res. 3 (1): 43–51. doi:10.2174/1570162052772988. PMID 15638722.
Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle.". Retrovirology 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=554975.
Kamibayashi C, Lickteig RL, Estes R, et al. (1992). "Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits.". J. Biol. Chem. 267 (30): 21864–72. PMID 1328247.
Tung HY, De Rocquigny H, Zhao LJ, et al. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.". FEBS Lett. 401 (2–3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886.
Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.
Strack S, Zaucha JA, Ebner FF, et al. (1998). "Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits". J. Comp. Neurol. 392 (4): 515–27. doi:10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3. PMID 9514514.
Griswold-Prenner I, Kamibayashi C, Maruoka EM, et al. (1998). "Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A". Mol. Cell. Biol. 18 (11): 6595–604. PMC 109244. PMID 9774674. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109244.
Ruediger R, Fields K, Walter G (1999). "Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens". J. Virol. 73 (1): 839–42. PMC 103900. PMID 9847399. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=103900.
Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
Moreno CS, Park S, Nelson K, et al. (2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". J. Biol. Chem. 275 (8): 5257–63. doi:10.1074/jbc.275.8.5257. PMID 10681496.
Husi H, Ward MA, Choudhary JS, et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698.
Hrimech M, Yao XJ, Branton PE, Cohen EA (2000). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 19 (15): 3956–67. doi:10.1093/emboj/19.15.3956. PMC 306605. PMID 10921877. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=306605.
Vogelsberg-Ragaglia V, Schuck T, Trojanowski JQ, Lee VM (2001). "PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus". Exp. Neurol. 168 (2): 402–12. doi:10.1006/exnr.2001.7630. PMID 11259128.
Elder RT, Yu M, Chen M, et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
Bennin DA, Don AS, Brake T, et al. (2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi:10.1074/jbc.M111693200. PMID 11956189.
Hrimech M, Yao XJ, Branton PE, Cohen EA (2002). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 21 (14): 3918. doi:10.1093/emboj/cdf420. PMC 126131. PMID 12110603. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126131.

PPP2R2A

Interactions

References

Further reading