PPP1R9A

Protein phosphatase 1, regulatory (inhibitor) subunit 9A

PDB rendering based on 1wf8.

Available structures
PDB	1wf8, 2fn5

Identifiers

PPP1R9A; FLJ20068; KIAA1222; NRB1; NRBI; Neurabin-I

External IDs

OMIM: 602468 MGI: 2442401 HomoloGene: 14247 GeneCards: PPP1R9A Gene

Gene Ontology
Molecular function	• actin binding
Cellular component	• cytoplasm • cytoskeleton • synaptosome • cell junction • filopodium • growth cone • cortical actin cytoskeleton • dendritic spine • synapse
Biological process	• actin filament organization • multicellular organismal development • nervous system development • cell differentiation • neuron projection development
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000158528

ENSMUSG00000032827

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
94.54 – 94.93 Mb

Chr 6:
4.85 – 5.12 Mb

PubMed search

Neurabin-1 is a protein that in humans is encoded by the PPP1R9A gene.^[1]^[2]

References

^ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
^ "Entrez Gene: PPP1R9A protein phosphatase 1, regulatory (inhibitor) subunit 9A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55607.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Nakanishi H, Obaishi H, Satoh A et al. (1997). "Neurabin: A Novel Neural Tissue–specific Actin Filament–binding Protein Involved in Neurite Formation". J. Cell Biol. 139 (4): 951–61. doi:10.1083/jcb.139.4.951. PMC 2139968. PMID 9362513. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2139968.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
McAvoy T, Allen PB, Obaishi H et al. (1999). "Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation". Biochemistry 38 (39): 12943–9. doi:10.1021/bi991227d. PMID 10504266.
Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. doi:10.1074/jbc.274.42.30080. PMID 10514494.
Oliver CJ, Terry-Lorenzo RT, Elliott E et al. (2002). "Targeting Protein Phosphatase 1 (PP1) to the Actin Cytoskeleton: the Neurabin I/PP1 Complex Regulates Cell Morphology". Mol. Cell. Biol. 22 (13): 4690–701. doi:10.1128/MCB.22.13.4690-4701.2002. PMC 133892. PMID 12052877. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133892.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Scherer SW, Cheung J, MacDonald JR et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961.
Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.

PDB gallery

1wf8: Solution structure of the PDZ domain of Spinophilin/NeurabinII protein

2fn5: NMR Structure of the Neurabin PDZ domain (502-594)