PPP1R3C

Protein phosphatase 1, regulatory (inhibitor) subunit 3C
Identifiers
Symbols PPP1R3C; PPP1R5
External IDs OMIM: 602999 MGI: 1858229 HomoloGene: 3938 GeneCards: PPP1R3C Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5507 53412
Ensembl ENSG00000119938 ENSMUSG00000067279
UniProt Q9UQK1 n/a
RefSeq (mRNA) NM_005398 NM_016854.2
RefSeq (protein) NP_005389 NP_058550.1
Location (UCSC) Chr 10:
93.39 – 93.39 Mb		 Chr 19:
36.81 – 36.81 Mb
PubMed search [1] [2]

Protein phosphatase 1 regulatory subunit 3C also known as PTG is an enzyme that in humans is encoded by the PPP1R3C gene.[1][2]

Function

Protein phosphatase-1 (PP1) participates in the regulation of a wide variety of cellular functions by reversible protein phosphorylation. The ability of PP1 to regulate diverse functions resides in its capacity to interact with a variety of regulatory subunits that may target PP1 to specific subcellular locations, modulate its substrate specificity, and allow its activity to be responsive to extracellular signals. Several targeting subunits of PP1 have been identified, including PPP1R5, the glycogen-binding subunits GM, GL, PTG and R6 and PPP1R4, and the nuclear inhibitor of PP1 (PPP1R8).[2]

References

  1. ^ Doherty MJ, Young PR, Cohen PT (Jan 1997). "Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1". FEBS Lett 399 (3): 339–43. doi:10.1016/S0014-5793(96)01357-9. PMID 8985175. 
  2. ^ a b "Entrez Gene: PPP1R3C protein phosphatase 1, regulatory (inhibitor) subunit 3C". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5507. 

Further reading