PPP1R2

Protein phosphatase 1, regulatory (inhibitor) subunit 2

Identifiers

PPP1R2; IPP2; MGC87148

External IDs

OMIM: 601792 MGI: 1914099 HomoloGene: 4546 GeneCards: PPP1R2 Gene

3.1.3.16

Gene Ontology
Molecular function	• protein serine/threonine phosphatase inhibitor activity • protein binding
Biological process	• carbohydrate metabolic process • glycogen metabolic process • generation of precursor metabolites and energy • regulation of signal transduction • regulation of phosphoprotein phosphatase activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
195.24 – 195.27 Mb

Chr 16:
31.17 – 31.2 Mb

PubMed search

[1]

[2]

Protein phosphatase inhibitor 2 is an enzyme that in humans is encoded by the PPP1R2 gene.^[1]^[2]^[3]

Interactions

PPP1R2 has been shown to interact with LMTK2^[4] and PPP1R9B.^[5]

References

^ Permana PA, Mott DM (May 1997). "Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians". Genomics 41 (1): 110–4. doi:10.1006/geno.1997.4649. PMID 9126490.
^ Helps NR, Street AJ, Elledge SJ, Cohen PT (Apr 1994). "Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli". FEBS Lett 340 (1-2): 93–8. doi:10.1016/0014-5793(94)80179-7. PMID 8119416.
^ "Entrez Gene: PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5504.
^ Wang, Hong; Brautigan David L (Dec. 2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". J. Biol. Chem. (United States) 277 (51): 49605–12. doi:10.1074/jbc.M209335200. ISSN 0021-9258. PMID 12393858.
^ Terry-Lorenzo, Ryan T; Elliot Elizabeth, Weiser Douglas C, Prickett Todd D, Brautigan David L, Shenolikar Shirish (Nov. 2002). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton". J. Biol. Chem. (United States) 277 (48): 46535–43. doi:10.1074/jbc.M206960200. ISSN 0021-9258. PMID 12270929.

Sanséau P, Jackson A, Alderton RP, et al. (1994). "Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences.". Mamm. Genome 5 (8): 490–6. doi:10.1007/BF00369318. PMID 7949733.
Park IK, Roach P, Bondor J, et al. (1994). "Molecular mechanism of the synergistic phosphorylation of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2.". J. Biol. Chem. 269 (2): 944–54. PMID 8288648.
Kakinoki Y, Somers J, Brautigan DL (1998). "Multisite phosphorylation and the nuclear localization of phosphatase inhibitor 2-green fluorescent protein fusion protein during S phase of the cell growth cycle.". J. Biol. Chem. 272 (51): 32308–14. doi:10.1074/jbc.272.51.32308. PMID 9405437.
Yang J, Hurley TD, DePaoli-Roach AA (2000). "Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif.". J. Biol. Chem. 275 (30): 22635–44. doi:10.1074/jbc.M003082200. PMID 10807923.
Agarwal-Mawal A, Paudel HK (2001). "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2.". J. Biol. Chem. 276 (26): 23712–8. doi:10.1074/jbc.M010002200. PMID 11320080.
Eto M, Elliott E, Prickett TD, Brautigan DL (2003). "Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation.". J. Biol. Chem. 277 (46): 44013–20. doi:10.1074/jbc.M208035200. PMID 12221103.
Terry-Lorenzo RT, Elliot E, Weiser DC, et al. (2003). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton.". J. Biol. Chem. 277 (48): 46535–43. doi:10.1074/jbc.M206960200. PMID 12270929.
Wang H, Brautigan DL (2003). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2.". J. Biol. Chem. 277 (51): 49605–12. doi:10.1074/jbc.M209335200. PMID 12393858.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Leach C, Shenolikar S, Brautigan DL (2003). "Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis.". J. Biol. Chem. 278 (28): 26015–20. doi:10.1074/jbc.M300782200. PMID 12697755.
Sakashita G, Shima H, Komatsu M, et al. (2004). "Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells.". J. Biochem. 133 (2): 165–71. doi:10.1093/jb/mvg020. PMID 12761178.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Yamada M, Ikeda Y, Yano M, et al. (2006). "Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy.". FASEB J. 20 (8): 1197–9. doi:10.1096/fj.05-5299fje. PMID 16627625.
King TD, Gandy JC, Bijur GN (2007). "The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels.". Exp. Cell Res. 312 (18): 3693–700. doi:10.1016/j.yexcr.2006.08.010. PMC 1885546. PMID 16987514. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1885546.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

PPP1R2

Interactions

References

Further reading