PPP1R13B
Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene.[1][2]
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.[2]
References
Further reading
- Liu ZJ, Lu X, Zhong S (2005). "ASPP--Apoptotic specific regulator of p53.". Biochim. Biophys. Acta 1756 (1): 77–80. doi:10.1016/j.bbcan.2005.08.002. PMID 16139958.
- Samuels-Lev Y, O'Connor DJ, Bergamaschi D, et al. (2001). "ASPP proteins specifically stimulate the apoptotic function of p53.". Mol. Cell 8 (4): 781–94. doi:10.1016/S1097-2765(01)00367-7. PMID 11684014.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bergamaschi D, Samuels Y, Jin B, et al. (2004). "ASPP1 and ASPP2: common activators of p53 family members.". Mol. Cell. Biol. 24 (3): 1341–50. doi:10.1128/MCB.24.3.1341-1350.2004. PMC 321425. PMID 14729977. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=321425.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
- Hershko T, Chaussepied M, Oren M, Ginsberg D (2005). "Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F.". Cell Death Differ. 12 (4): 377–83. doi:10.1038/sj.cdd.4401575. PMID 15706352.
- Fogal V, Kartasheva NN, Trigiante G, et al. (2005). "ASPP1 and ASPP2 are new transcriptional targets of E2F.". Cell Death Differ. 12 (4): 369–76. doi:10.1038/sj.cdd.4401562. PMID 15731768.
- Liu ZJ, Lu X, Zhang Y, et al. (2005). "Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53.". FEBS Lett. 579 (7): 1587–90. doi:10.1016/j.febslet.2005.01.069. PMID 15757645.
- Bergamaschi D, Samuels Y, Zhong S, Lu X (2005). "Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation.". Oncogene 24 (23): 3836–41. doi:10.1038/sj.onc.1208535. PMID 15782125.
- Agirre X, Román-Gómez J, Jiménez-Velasco A, et al. (2006). "ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia.". Oncogene 25 (13): 1862–70. doi:10.1038/sj.onc.1209236. PMID 16314841.