PPP1CC

Protein phosphatase 1, catalytic subunit, gamma isozyme

PDB rendering based on 1fjm.

Available structures
PDB	1IT6, 1JK7, 1U32, 2BCD, 2BDX

Identifiers

Symbols

PPP1CC; PP-1G; PPP1G

External IDs

OMIM: 176914 MGI: 104872 HomoloGene: 100608 GeneCards: PPP1CC Gene

EC number

3.1.3.16

Gene Ontology
Molecular function	• protein serine/threonine phosphatase activity • protein binding • hydrolase activity • protein kinase binding • metal ion binding
Cellular component	• condensed chromosome kinetochore • nucleus • nucleoplasm • chromosome • nucleolus • cytoplasm • mitochondrion • mitochondrial outer membrane • cytosol • nuclear speck • midbody • cleavage furrow • protein complex • MLL5-L complex • PTW/PP1 phosphatase complex
Biological process	• M phase of mitotic cell cycle • mitotic prometaphase • mitotic cell cycle • carbohydrate metabolic process • glycogen metabolic process • protein dephosphorylation • lipid metabolic process • triglyceride catabolic process • regulation of nucleocytoplasmic transport • cell division
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
111.16 – 111.18 Mb

Chr 5:
122.61 – 122.63 Mb

PubMed search

[1]

[2]

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.^[1]

Interactions

PPP1CC has been shown to interact with PPP1R15A,^[2]^[3] SMARCB1,^[2] TLX1^[4] and PPP1R9B.^[5]^[6]

References

^ "Entrez Gene: PPP1CC Protein phosphatase 1, catalytic subunit, gamma isoform". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5501.
^ ^a ^b Wu, Daniel Y; Tkachuck Douglas C, Roberson Rachel S, Schubach William H (Aug. 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. (United States) 277 (31): 27706–15. doi:10.1074/jbc.M200955200. ISSN 0021-9258. PMID 12016208.
^ Connor, J H; Weiser D C, Li S, Hallenbeck J M, Shenolikar S (Oct. 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Mol. Cell. Biol. (United States) 21 (20): 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. ISSN 0270-7306. PMC 99861. PMID 11564868. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99861.
^ Kawabe, T; Muslin A J, Korsmeyer S J (Jan. 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature (ENGLAND) 385 (6615): 454–8. doi:10.1038/385454a0. ISSN 0028-0836. PMID 9009195.
^ Hsieh-Wilson, L C; Allen P B, Watanabe T, Nairn A C, Greengard P (Apr. 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry (UNITED STATES) 38 (14): 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.
^ Smith, F D; Oxford G S, Milgram S L (Jul. 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". J. Biol. Chem. (UNITED STATES) 274 (28): 19894–900. doi:10.1074/jbc.274.28.19894. ISSN 0021-9258. PMID 10391935.

Van Eynde A, Wera S, Beullens M, et al. (1996). "Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing.". J. Biol. Chem. 270 (47): 28068–74. doi:10.1074/jbc.270.47.28068. PMID 7499293.
Egloff MP, Cohen PT, Reinemer P, Barford D (1996). "Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate.". J. Mol. Biol. 254 (5): 942–59. doi:10.1006/jmbi.1995.0667. PMID 7500362.
MacKintosh RW, Dalby KN, Campbell DG, et al. (1995). "The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1.". FEBS Lett. 371 (3): 236–40. doi:10.1016/0014-5793(95)00888-G. PMID 7556599.
Norman SA, Mott DM (1994). "Molecular cloning and chromosomal localization of a human skeletal muscle PP-1 gamma 1 cDNA.". Mamm. Genome 5 (1): 41–5. doi:10.1007/BF00360567. PMID 8111128.
Barker HM, Craig SP, Spurr NK, Cohen PT (1993). "Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2.". Biochim. Biophys. Acta 1178 (2): 228–33. doi:10.1016/0167-4889(93)90014-G. PMID 8394140.
Helps NR, Barker HM, Elledge SJ, Cohen PT (1996). "Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53.". FEBS Lett. 377 (3): 295–300. doi:10.1016/0014-5793(95)01347-4. PMID 8549741.
Saadat M, Nomoto K, Mizuno Y, et al. (1996). "Assignment of the gene encoding type 1 gamma protein phosphatase catalytic subunit (PPP1CC) on human, rat, and mouse chromosomes.". Jpn. J. Hum. Genet. 41 (1): 159–65. doi:10.1007/BF01892623. PMID 8914631.
Armstrong CG, Browne GJ, Cohen P, Cohen PT (1998). "PPP1R6, a novel member of the family of glycogen-targeting subunits of protein phosphatase 1.". FEBS Lett. 418 (1-2): 210–4. doi:10.1016/S0014-5793(97)01385-9. PMID 9414128.
Andreassen PR, Lacroix FB, Villa-Moruzzi E, Margolis RL (1998). "Differential subcellular localization of protein phosphatase-1 alpha, gamma1, and delta isoforms during both interphase and mitosis in mammalian cells.". J. Cell Biol. 141 (5): 1207–15. doi:10.1083/jcb.141.5.1207. PMC 2137188. PMID 9606212. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2137188.
Ajuh PM, Browne GJ, Hawkes NA, et al. (2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex.". Nucleic Acids Res. 28 (3): 678–86. doi:10.1093/nar/28.3.678. PMC 102561. PMID 10637318. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=102561.
Yang J, Hurley TD, DePaoli-Roach AA (2000). "Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif.". J. Biol. Chem. 275 (30): 22635–44. doi:10.1074/jbc.M003082200. PMID 10807923.
Katayama H, Zhou H, Li Q, et al. (2002). "Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle.". J. Biol. Chem. 276 (49): 46219–24. doi:10.1074/jbc.M107540200. PMID 11551964.
Patel KG, Liu C, Cameron PL, Cameron RS (2001). "Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1.". J. Neurosci. 21 (20): 7954–68. PMID 11588169.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Jones JA, Hannun YA (2002). "Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid.". J. Biol. Chem. 277 (18): 15530–8. doi:10.1074/jbc.M111555200. PMID 11856740.
Wu DY, Tkachuck DC, Roberson RS, Schubach WH (2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.". J. Biol. Chem. 277 (31): 27706–15. doi:10.1074/jbc.M200955200. PMID 12016208.
Bharucha DC, Zhou M, Nekhai S, et al. (2002). "A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat.". Virology 296 (1): 6–16. doi:10.1006/viro.2002.1438. PMID 12036313.
Tan SL, Tareen SU, Melville MW, et al. (2002). "The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.". J. Biol. Chem. 277 (39): 36109–17. doi:10.1074/jbc.M205109200. PMID 12138106.
Eto M, Elliott E, Prickett TD, Brautigan DL (2003). "Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation.". J. Biol. Chem. 277 (46): 44013–20. doi:10.1074/jbc.M208035200. PMID 12221103.
Ceulemans H, Vulsteke V, De Maeyer M, et al. (2003). "Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.". J. Biol. Chem. 277 (49): 47331–7. doi:10.1074/jbc.M206838200. PMID 12226088.

PDB gallery

1fjm: PROTEIN SERINE/THREONINE PHOSPHATASE-1 (ALPHA ISOFORM, TYPE I) COMPLEXED WITH MICROCYSTIN-LR TOXIN

1it6: CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CALYCULIN A AND THE CATALYTIC SUBUNIT OF PROTEIN PHOSPHATASE 1

1jk7: CRYSTAL STRUCTURE OF THE TUMOR-PROMOTER OKADAIC ACID BOUND TO PROTEIN PHOSPHATASE-1

1u32: Crystal structure of a Protein Phosphatase-1: Calcineurin Hybrid Bound to Okadaic Acid

2bcd: X-ray crystal structure of Protein Phosphatase-1 with the marine toxin motuporin bound

2bdx: X-ray Crystal Structure of dihydromicrocystin-LA bound to Protein Phosphatase-1

PPP1CC

Interactions

References

Further reading