PPIL1

Peptidylprolyl isomerase (cyclophilin)-like 1

PDB rendering based on 1xwn.
Identifiers
Symbols PPIL1; CYPL1; MGC678; PPIase; hCyPX
External IDs OMIM: 601301 MGI: 1916066 HomoloGene: 9367 GeneCards: PPIL1 Gene
EC number 5.2.1.8
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 51645 68816
Ensembl ENSG00000137168 ENSMUSG00000024007
UniProt Q9Y3C6 n/a
RefSeq (mRNA) NM_016059 NM_026845.4
RefSeq (protein) NP_057143 NP_081121.1
Location (UCSC) Chr 6:
36.82 – 36.84 Mb		 Chr 17:
29.39 – 29.4 Mb
PubMed search [1] [2]

Peptidyl-prolyl cis-trans isomerase-like 1 is an enzyme that in humans is encoded by the PPIL1 gene.[1][2][3]

This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[3]

References

  1. ^ Mann SS, Pettenati MJ, von Kap-herr C, Hart TC (Mar 1999). "Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization". Cytogenet Cell Genet 83 (3-4): 228–9. doi:10.1159/000015186. PMID 10072585. 
  2. ^ Ozaki K, Fujiwara T, Kawai A, Shimizu F, Takami S, Okuno S, Takeda S, Shimada Y, Nagata M, Watanabe T, Takaichi A, Takahashi E, Nakamura Y, Shin S (Jan 1997). "Cloning, expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain". Cytogenet Cell Genet 72 (2-3): 242–5. doi:10.1159/000134199. PMID 8978786. 
  3. ^ a b "Entrez Gene: PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51645. 

Further reading