PPIH
Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.[1][2][3]
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.[3]
References
Further reading
- Reidt U, Reuter K, Achsel T et al. (2000). "Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin". J. Biol. Chem. 275 (11): 7439–42. doi:10.1074/jbc.275.11.7439. PMID 10713041.
- Horowitz DS, Lee EJ, Mabon SA, Misteli T (2002). "A cyclophilin functions in pre-mRNA splicing". EMBO J. 21 (3): 470–80. doi:10.1093/emboj/21.3.470. PMC 125845. PMID 11823439. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125845.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Reidt U, Wahl MC, Fasshauer D et al. (2003). "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide". J. Mol. Biol. 331 (1): 45–56. doi:10.1016/S0022-2836(03)00684-3. PMID 12875835.
- Ingelfinger D, Göthel SF, Marahiel MA et al. (2004). "Two protein–protein interaction sites on the spliceosome-associated human cyclophilin CypH". Nucleic Acids Res. 31 (16): 4791–6. doi:10.1093/nar/gkg660. PMC 169899. PMID 12907720. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=169899.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Andersen JS, Lam YW, Leung AK et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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PDB gallery
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1mzw: Crystal structure of a U4/U6 snRNP complex between human spliceosomal cyclophilin H and a U4/U6-60K peptide
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1qoi: U4/U6 SNRNP-SPECIFIC CYCLOPHILIN SNUCYP-20
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