POLR2J

Polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa

Identifiers

POLR2J; MGC71910; POLR2J1; RPB11; RPB11A; RPB11m; hRPB14

External IDs

OMIM: 604150 MGI: 109582 HomoloGene: 4542 GeneCards: POLR2J Gene

2.7.7.6

Gene Ontology
Molecular function	• DNA binding • DNA-directed RNA polymerase activity • protein kinase activity • protein binding • LRR domain binding • protein dimerization activity
Cellular component	• nucleus • nucleoplasm • nucleoplasm • DNA-directed RNA polymerase II, core complex
Biological process	• nuclear mRNA splicing, via spliceosome • DNA repair • transcription-coupled nucleotide-excision repair • nucleotide-excision repair • transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • mRNA capping • protein phosphorylation • RNA splicing • gene expression • viral reproduction • positive regulation of viral transcription
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
102.11 – 102.12 Mb

Chr 5:
136.59 – 136.6 Mb

PubMed search

[1]

[2]

DNA-directed RNA polymerase II subunit RPB11-a is an enzyme that in humans is encoded by the POLR2J gene.

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13.^[1]

Interactions

POLR2J has been shown to interact with POLR2C,^[2]^[3] SATB1^[4] and Apoptosis antagonizing transcription factor.^[5]

References

^ "Entrez Gene: POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5439.
^ Acker, J; de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (Jul. 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. (UNITED STATES) 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987.
^ Corbi, Nicoletta; Di Padova Monica, De Angelis Roberta, Bruno Tiziana, Libri Valentina, Iezzi Simona, Floridi Aristide, Fanciulli Maurizio, Passananti Claudio (Oct. 2002). "The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin". FASEB J. (United States) 16 (12): 1639–41. doi:10.1096/fj.02-0123fje. PMID 12207009.
^ Durrin, Linda K; Krontiris Theodore G (Jun. 2002). "The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11". Genomics (United States) 79 (6): 809–17. doi:10.1006/geno.2002.6772. ISSN 0888-7543. PMID 12036295.
^ Fanciulli, M; Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C (May. 2000). "Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb". FASEB J. (UNITED STATES) 14 (7): 904–12. ISSN 0892-6638. PMID 10783144.

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POLR2J

Interactions

References

Further reading