POLG2
DNA polymerase subunit gamma-2, mitochondrial is an protein that in humans is encoded by the POLG2 gene. The POLG2 gene encodes a 55 kDa accessory subunit protein that imparts high processivity and salt tolerance to the catalytic subunit of DNA polymerase gamma, encoded by the POLG gene. [1][2][3]
References
- ^ Wang Y, Farr CL, Kaguni LS (Jul 1997). "Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme". J Biol Chem 272 (21): 13640–6. doi:10.1074/jbc.272.21.13640. PMID 9153213.
- ^ "Entrez Gene: POLG2 polymerase (DNA directed), gamma 2, accessory subunit". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11232.
- ^ Lim SE, Longley MJ, Copeland WC (1999). "The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance". J. Biol. Chem. 274 (53): 38197–203. doi:10.1074/jbc.274.53.38197. PMID 10608893.
Further reading
- Michiels S, Danoy P, Dessen P, et al. (2007). "Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers.". Carcinogenesis 28 (8): 1731–9. doi:10.1093/carcin/bgm111. PMID 17494052.
- Huang H, Shiffman ML, Cheung RC, et al. (2006). "Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C.". Gastroenterology 130 (6): 1679–87. doi:10.1053/j.gastro.2006.02.032. PMID 16697732.
- Longley MJ, Clark S, Yu Wai Man C, et al. (2006). "Mutant POLG2 Disrupts DNA Polymerase γ Subunits and Causes Progressive External Ophthalmoplegia". Am. J. Hum. Genet. 78 (6): 1026–34. doi:10.1086/504303. PMC 1474082. PMID 16685652. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1474082.
- Yakubovskaya E, Chen Z, Carrodeguas JA, et al. (2006). "Functional human mitochondrial DNA polymerase gamma forms a heterotrimer". J. Biol. Chem. 281 (1): 374–82. doi:10.1074/jbc.M509730200. PMID 16263719.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Carrodeguas JA, Pinz KG, Bogenhagen DF (2003). "DNA binding properties of human pol gammaB". J. Biol. Chem. 277 (51): 50008–14. doi:10.1074/jbc.M207030200. PMID 12379656.
- Johnson AA, Tsai Y, Graves SW, Johnson KA (2000). "Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization". Biochemistry 39 (7): 1702–8. doi:10.1021/bi992104w. PMID 10677218.
- Carrodeguas JA, Bogenhagen DF (2000). "Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase". Nucleic Acids Res. 28 (5): 1237–44. doi:10.1093/nar/28.5.1237. PMC 102604. PMID 10666468. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=102604.
- Lim SE, Longley MJ, Copeland WC (1999). "The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance". J. Biol. Chem. 274 (53): 38197–203. doi:10.1074/jbc.274.53.38197. PMID 10608893.
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PDB gallery
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2g4c: Crystal Structure of human DNA polymerase gamma accessory subunit
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