PMS2

PMS2 postmeiotic segregation increased 2 (S. cerevisiae)

PDB rendering based on 1ea6.

Available structures
PDB	1EA6, 1H7S, 1H7U

Identifiers

Symbols

PMS2; HNPCC4; PMS2CL; PMSL2

External IDs

OMIM: 600259 MGI: 104288 HomoloGene: 450 GeneCards: PMS2 Gene

Gene Ontology
Molecular function	• DNA binding • single-stranded DNA binding • endonuclease activity • protein binding • ATP binding • hydrolase activity • ATPase activity • mismatched DNA binding • single base insertion or deletion binding • MutSalpha complex binding
Cellular component	• nucleus • MutLalpha complex
Biological process	• ATP catabolic process • mismatch repair • reciprocal meiotic recombination • somatic hypermutation of immunoglobulin genes • somatic recombination of immunoglobulin gene segments • response to drug
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
6.01 – 6.05 Mb

Chr 5:
144.67 – 144.7 Mb

PubMed search

[1]

[2]

Mismatch repair endonuclease PMS2 is an enzyme that in humans is encoded by the PMS2 gene.^[1]

This gene is one of the PMS2 gene family members which are found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. The protein forms a heterodimer with MLH1 and this complex interacts with MSH2 bound to mismatched bases. Defects in this gene are associated with hereditary nonpolyposis colorectal cancer, with Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed.^[2]

1 Interactions
2 References
3 Further reading
4 External links

Interactions

PMS2 has been shown to interact with MLH1.^[3]^[4]^[5]

References

^ Nicolaides NC, Papadopoulos N, Liu B, Wei YF, Carter KC, Ruben SM, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, et al. (Sep 1994). "Mutations of two PMS homologues in hereditary nonpolyposis colon cancer". Nature 371 (6492): 75–80. doi:10.1038/371075a0. PMID 8072530.
^ "Entrez Gene: PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5395.
^ Mac Partlin, Mary; Homer Elizabeth, Robinson Helen, McCormick Carol J, Crouch Dorothy H, Durant Stephen T, Matheson Elizabeth C, Hall Andrew G, Gillespie David A F, Brown Robert (Feb. 2003). "Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX". Oncogene (England) 22 (6): 819–25. doi:10.1038/sj.onc.1206252. ISSN 0950-9232. PMID 12584560.
^ Kondo, E; Horii A, Fukushige S (Apr. 2001). "The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2". Nucleic Acids Res. (England) 29 (8): 1695–702. doi:10.1093/nar/29.8.1695. PMC 31313. PMID 11292842. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=31313.
^ Guerrette, S; Acharya S, Fishel R (Mar. 1999). "The interaction of the human MutL homologues in hereditary nonpolyposis colon cancer". J. Biol. Chem. (UNITED STATES) 274 (10): 6336–41. doi:10.1074/jbc.274.10.6336. ISSN 0021-9258. PMID 10037723.

Kolodner RD, Marsischky GT (1999). "Eukaryotic DNA mismatch repair.". Curr. Opin. Genet. Dev. 9 (1): 89–96. doi:10.1016/S0959-437X(99)80013-6. PMID 10072354.
de Vos M, Hayward B, Bonthron DT, Sheridan E (2005). "Phenotype associated with recessively inherited mutations in DNA mismatch repair (MMR) genes.". Biochem. Soc. Trans. 33 (Pt 4): 718–20. doi:10.1042/BST0330718. PMID 16042583.
Hamilton SR, Liu B, Parsons RE, et al. (1995). "The molecular basis of Turcot's syndrome.". N. Engl. J. Med. 332 (13): 839–47. doi:10.1056/NEJM199503303321302. PMID 7661930.
Nicolaides NC, Carter KC, Shell BK, et al. (1996). "Genomic organization of the human PMS2 gene family.". Genomics 30 (2): 195–206. doi:10.1006/geno.1995.9885. PMID 8586419.
Nicolaides NC, Kinzler KW, Vogelstein B (1996). "Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene.". Genomics 29 (2): 329–34. doi:10.1006/geno.1995.9997. PMID 8666379.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Meyers M, Theodosiou M, Acharya S, et al. (1997). "Cell cycle regulation of the human DNA mismatch repair genes hMSH2, hMLH1, and hPMS2.". Cancer Res. 57 (2): 206–8. PMID 9000555.
Miyaki M, Nishio J, Konishi M, et al. (1998). "Drastic genetic instability of tumors and normal tissues in Turcot syndrome.". Oncogene 15 (23): 2877–81. doi:10.1038/sj.onc.1201668. PMID 9419979.
Guerrette S, Acharya S, Fishel R (1999). "The interaction of the human MutL homologues in hereditary nonpolyposis colon cancer.". J. Biol. Chem. 274 (10): 6336–41. doi:10.1074/jbc.274.10.6336. PMID 10037723.
Wang Q, Lasset C, Desseigne F, et al. (1999). "Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer.". Hum. Genet. 105 (1–2): 79–85. doi:10.1007/s004390051067. PMID 10480359.
Matton N, Simonetti J, Williams K (2000). "Identification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNA". J. Biol. Chem. 275 (23): 17808–13. doi:10.1074/jbc.M909794199. PMID 10748159.
De Rosa M, Fasano C, Panariello L, et al. (2000). "Evidence for a recessive inheritance of Turcot's syndrome caused by compound heterozygous mutations within the PMS2 gene". Oncogene 19 (13): 1719–23. doi:10.1038/sj.onc.1203447. PMID 10763829.
Wang Y, Cortez D, Yazdi P, et al. (2000). "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures". Genes Dev. 14 (8): 927–39. PMC 316544. PMID 10783165. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316544.
Ceccotti S, Ciotta C, Fronza G, et al. (2000). "Multiple mutations and frameshifts are the hallmark of defective hPMS2 in pZ189-transfected human tumor cells". Nucleic Acids Res. 28 (13): 2577–84. doi:10.1093/nar/28.13.2577. PMC 102707. PMID 10871409. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=102707.
Christmann M, Kaina B (2000). "Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents". J. Biol. Chem. 275 (46): 36256–62. doi:10.1074/jbc.M005377200. PMID 10954713.
Kondo E, Horii A, Fukushige S (2001). "The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2". Nucleic Acids Res. 29 (8): 1695–702. doi:10.1093/nar/29.8.1695. PMC 31313. PMID 11292842. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=31313.
Schmutte C, Sadoff MM, Shim KS, et al. (2001). "The interaction of DNA mismatch repair proteins with human exonuclease I". J. Biol. Chem. 276 (35): 33011–8. doi:10.1074/jbc.M102670200. PMID 11427529.
Jäger AC, Rasmussen M, Bisgaard HC, et al. (2001). "HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes". Oncogene 20 (27): 3590–5. doi:10.1038/sj.onc.1204467. PMID 11429708.

PDB gallery

1ea6: N-TERMINAL 40KDA FRAGMENT OF NHPMS2 COMPLEXED WITH ADP

1h7s: N-TERMINAL 40KDA FRAGMENT OF HUMAN PMS2

1h7u: HPMS2-ATPGS

PMS2

Contents

Interactions

References

Further reading

External links