Plexin A1

Identifiers

PLXNA1; DKFZp761P19121; NOV; NOVP; PLEXIN-A1; PLXN1

External IDs

OMIM: 601055 MGI: 107685 HomoloGene: 56426 GeneCards: PLXNA1 Gene

Gene Ontology
Molecular function	• receptor activity • semaphorin receptor activity
Cellular component	• intracellular • plasma membrane • plasma membrane • integral to membrane
Biological process	• signal transduction • multicellular organismal development • axon guidance
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
126.71 – 126.76 Mb

Chr 6:
89.27 – 89.31 Mb

PubMed search

[1]

[2]

Plexin-A1 is a protein that in humans is encoded by the PLXNA1 gene.^[1]^[2]

Interactions

Plexin A1 has been shown to interact with AKT1.^[3]

References

^ Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci U S A 93 (2): 674–8. doi:10.1073/pnas.93.2.674. PMC 40111. PMID 8570614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=40111.
^ "Entrez Gene: PLXNA1 plexin A1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5361.
^ Turner, Laura J; Nicholls Sarah, Hall Alan (Aug. 2004). "The activity of the plexin-A1 receptor is regulated by Rac". J. Biol. Chem. (United States) 279 (32): 33199–205. doi:10.1074/jbc.M402943200. ISSN 0021-9258. PMID 15187088.

Takahashi T, Fournier A, Nakamura F, et al. (1999). "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.". Cell 99 (1): 59–69. doi:10.1016/S0092-8674(00)80062-8. PMID 10520994.
Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.". Cell 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
Rohm B, Rahim B, Kleiber B, et al. (2001). "The semaphorin 3A receptor may directly regulate the activity of small GTPases.". FEBS Lett. 486 (1): 68–72. doi:10.1016/S0014-5793(00)02240-7. PMID 11108845.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Takahashi T, Strittmatter SM (2001). "Plexina1 autoinhibition by the plexin sema domain.". Neuron 29 (2): 429–39. doi:10.1016/S0896-6273(01)00216-1. PMID 11239433.
Zanata SM, Hovatta I, Rohm B, Püschel AW (2002). "Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse.". J. Neurosci. 22 (2): 471–7. PMID 11784792.
Mitsui N, Inatome R, Takahashi S, et al. (2002). "Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling.". EMBO J. 21 (13): 3274–85. doi:10.1093/emboj/cdf328. PMC 125392. PMID 12093729. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125392.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Usui H, Taniguchi M, Yokomizo T, Shimizu T (2003). "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains.". Biochem. Biophys. Res. Commun. 300 (4): 927–31. doi:10.1016/S0006-291X(02)02966-2. PMID 12559962.
Bachelder RE, Lipscomb EA, Lin X, et al. (2003). "Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells.". Cancer Res. 63 (17): 5230–3. PMID 14500350.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Toyofuku T, Zhang H, Kumanogoh A, et al. (2004). "Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2.". Genes Dev. 18 (4): 435–47. doi:10.1101/gad.1167304. PMC 359397. PMID 14977921. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=359397.
Turner LJ, Nicholls S, Hall A (2004). "The activity of the plexin-A1 receptor is regulated by Rac.". J. Biol. Chem. 279 (32): 33199–205. doi:10.1074/jbc.M402943200. PMID 15187088.
Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3.". Nature 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.

Plexin A1

Interactions

References

Further reading