PLEK2

Pleckstrin 2

PDB rendering based on 1v3f.

Available structures
PDB	1v3f, 1x1g

Identifiers

Symbols

PLEK2;

External IDs

OMIM: 608007 MGI: 1351466 HomoloGene: 8447 GeneCards: PLEK2 Gene

Gene Ontology
Cellular component	• cytoplasm • cytoskeleton • plasma membrane • lamellipodium membrane • cell projection
Biological process	• actin cytoskeleton organization • intracellular signal transduction
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
67.85 – 67.88 Mb

Chr 12:
79.99 – 80.01 Mb

PubMed search

[1]

[2]

Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene.^[1]^[2]^[3] The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left^[4].

References

^ Lemmon MA, Ferguson KM, Abrams CS (Mar 2002). "Pleckstrin homology domains and the cytoskeleton". FEBS Lett 513 (1): 71–6. doi:10.1016/S0014-5793(01)03243-4. PMID 11911883.
^ Hamaguchi N, Ihara S, Ohdaira T, Nagano H, Iwamatsu A, Tachikawa H, Fukui Y (Aug 2007). "Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading". Biochem Biophys Res Commun 361 (2): 270–5. doi:10.1016/j.bbrc.2007.06.132. PMID 17658464.
^ "Entrez Gene: PLEK2 pleckstrin 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26499.
^ "AceView: PLEK2 gene". AceView. National Library of Medicine. http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&term=PLEK2&submit=Go. Retrieved 24 April 2011.

Bach TL, Kerr WT, Wang Y, et al. (2007). "PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization.". Blood 109 (3): 1147–55. doi:10.1182/blood-2006-02-001339. PMC 1785144. PMID 17008542. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1785144.
Inazu T, Kuroiwa A, Matsuda Y, Miyamoto K (2005). "Cloning, expression and chromosomal assignment of human pleckstrin 2.". Mol. Biol. Rep. 32 (1): 35–40. doi:10.1007/s11033-004-4747-x. PMID 15865208.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Inazu T, Yamada K, Miyamoto K (1999). "Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family.". Biochem. Biophys. Res. Commun. 265 (1): 87–93. doi:10.1006/bbrc.1999.1461. PMID 10548495.
Hu MH, Bauman EM, Roll RL, et al. (1999). "Pleckstrin 2, a widely expressed paralog of pleckstrin involved in actin rearrangement.". J. Biol. Chem. 274 (31): 21515–8. doi:10.1074/jbc.274.31.21515. PMID 10419454.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.

PDB gallery

1v3f: Solution structure of the DEP domain of mouse pleckstrin2

1x1g: Solution structure of the C-terminal PH domain of human pleckstrin 2

PLEK2

References

Further reading