PLAGL1
Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.[1][2][3]
This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.[3]
Interactions
PLAGL1 has been shown to interact with P53.[4]
References
- ^ Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ (Oct 1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J Biol Chem 273 (36): 23026–32. doi:10.1074/jbc.273.36.23026. PMID 9722527.
- ^ Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L (Aug 1998). "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer". Proc Natl Acad Sci U S A 95 (15): 8835–40. doi:10.1073/pnas.95.15.8835. PMC 21163. PMID 9671765. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21163.
- ^ a b "Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5325.
- ^ Huang, S M; Schönthal A H, Stallcup M R (Apr. 2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene (England) 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. ISSN 0950-9232. PMID 11360197.
Further reading
- Vernon M (2005). "Fifty years of research on the intelligence of deaf and hard-of-hearing children: a review of literature and discussion of implications.". Journal of deaf studies and deaf education 10 (3): 225–31. doi:10.1093/deafed/eni024. PMID 15888725.
- Abdollahi A, Roberts D, Godwin AK, et al. (1997). "Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors.". Oncogene 14 (16): 1973–9. doi:10.1038/sj.onc.1201034. PMID 9150364.
- Abdollahi A, Godwin AK, Miller PD, et al. (1997). "Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells.". Cancer Res. 57 (10): 2029–34. PMID 9158001.
- Spengler D, Villalba M, Hoffmann A, et al. (1997). "Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain.". EMBO J. 16 (10): 2814–25. doi:10.1093/emboj/16.10.2814. PMC 1169890. PMID 9184226. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169890.
- Abdollahi A, Bao R, Hamilton TC (2000). "LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein.". Oncogene 18 (47): 6477–87. doi:10.1038/sj.onc.1203067. PMID 10597250.
- Kamiya M, Judson H, Okazaki Y, et al. (2000). "The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes.". Hum. Mol. Genet. 9 (3): 453–60. doi:10.1093/hmg/9.3.453. PMID 10655556.
- Bilanges B, Varrault A, Mazumdar A, et al. (2001). "Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities.". Oncogene 20 (10): 1246–53. doi:10.1038/sj.onc.1204237. PMID 11313869.
- Huang SM, Schönthal AH, Stallcup MR (2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1.". Oncogene 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197.
- Mackay DJ, Coupe AM, Shield JP, et al. (2002). "Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus.". Hum. Genet. 110 (2): 139–44. doi:10.1007/s00439-001-0671-5. PMID 11935319.
- Abdollahi A, Pisarcik D, Roberts D, et al. (2003). "LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer.". J. Biol. Chem. 278 (8): 6041–9. doi:10.1074/jbc.M210361200. PMID 12473647.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Hoffmann A, Ciani E, Boeckardt J, et al. (2003). "Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding.". Mol. Cell. Biol. 23 (3): 988–1003. doi:10.1128/MCB.23.3.988-1003.2003. PMC 140694. PMID 12529403. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=140694.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
- Ma D, Shield JP, Dean W, et al. (2004). "Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM.". J. Clin. Invest. 114 (3): 339–48. doi:10.1172/JCI200419876. PMC 484972. PMID 15286800. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=484972.
- Cvetkovic D, Pisarcik D, Lee C, et al. (2005). "Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer.". Gynecol. Oncol. 95 (3): 449–55. doi:10.1016/j.ygyno.2004.08.051. PMID 15581945.
- Mitchell J, Punthakee Z, Lo B, et al. (2005). "Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome.". Diabetologia 47 (12): 2160–7. doi:10.1007/s00125-004-1576-3. PMID 15592663.