PKP3
Plakophilin-3 is a protein that in humans is encoded by the PKP3 gene.[1][2]
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.[2]
Interactions
PKP3 has been shown to interact with Desmoglein 3,[3] DSC3,[3] Desmoglein 2[3] and Desmoglein 1.[3]
References
- ^ Schmidt A, Langbein L, Pratzel S, Rode M, Rackwitz HR, Franke WW (Jun 1999). "Plakophilin 3--a novel cell-type-specific desmosomal plaque protein". Differentiation 64 (5): 291–306. doi:10.1046/j.1432-0436.1999.6450291.x. PMID 10374265.
- ^ a b "Entrez Gene: PKP3 plakophilin 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11187.
- ^ a b c d Bonné, Stefan; Gilbert Barbara, Hatzfeld Mechthild, Chen Xinyu, Green Kathleen J, van Roy Frans (Apr. 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. (United States) 161 (2): 403–16. doi:10.1083/jcb.200303036. ISSN 0021-9525. PMC 2172904. PMID 12707304. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172904.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Bonné S, van Hengel J, Nollet F, et al. (1999). "Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells.". J. Cell. Sci. 112 ( Pt 14): 2265–76. PMID 10381383.
- Hofmann I, Mertens C, Brettel M, et al. (2000). "Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis.". J. Cell. Sci. 113 ( Pt 13): 2471–83. PMID 10852826.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Bonné S, Gilbert B, Hatzfeld M, et al. (2003). "Defining desmosomal plakophilin-3 interactions.". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904. PMID 12707304. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172904.
- Papagerakis S, Shabana AH, Depondt J, et al. (2003). "Immunohistochemical localization of plakophilins (PKP1, PKP2, PKP3, and p0071) in primary oropharyngeal tumors: correlation with clinical parameters.". Hum. Pathol. 34 (6): 565–72. doi:10.1016/S0046-8177(03)00174-6. PMID 12827610.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
- Hofmann I, Casella M, Schnölzer M, et al. (2006). "Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules.". Mol. Biol. Cell 17 (3): 1388–98. doi:10.1091/mbc.E05-08-0708. PMC 1382326. PMID 16407409. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1382326.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- Aigner K, Descovich L, Mikula M, et al. (2007). "The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression.". FEBS Lett. 581 (8): 1617–24. doi:10.1016/j.febslet.2007.03.026. PMC 2938730. PMID 17391671. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2938730.