PKMYT1

Protein kinase, membrane associated tyrosine/threonine 1
Identifiers
Symbols PKMYT1; DKFZp547K1610; FLJ20093; MYT1
External IDs OMIM602474 MGI2137630 HomoloGene31227 GeneCards: PKMYT1 Gene
EC number 2.7.11.1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 9088 268930
Ensembl ENSG00000127564 ENSMUSG00000023908
UniProt Q99640 Q3TNN2
RefSeq (mRNA) NM_004203.4 NM_023058.3
RefSeq (protein) NP_004194.3 NP_075545.2
Location (UCSC) Chr 16:
3.02 – 3.03 Mb
Chr 17:
23.86 – 23.87 Mb
PubMed search [1] [2]

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase is an enzyme that in humans is encoded by the PKMYT1 gene.[1][2][3]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

Interactions

PKMYT1 has been shown to interact with PIN1[4] and STEAP3.[2]

References

Further reading