PINX1

PIN2/TERF1 interacting, telomerase inhibitor 1

Identifiers

PINX1; FLJ20565; LPTL; LPTS; MGC8850

External IDs

OMIM: 606505 MGI: 1919650 HomoloGene: 31531 GeneCards: PINX1 Gene

Gene Ontology
Molecular function	• nucleic acid binding • protein binding • telomerase inhibitor activity • telomeric RNA binding
Cellular component	• nuclear chromosome • kinetochore • condensed chromosome kinetochore • chromosome, telomeric region • intracellular • nucleus • nucleolus • cytoplasm • mitochondrion • spindle • intracellular membrane-bounded organelle
Biological process	• telomere maintenance via telomerase • mitotic metaphase plate congression • negative regulation of cell proliferation • regulation of telomerase activity • negative regulation of telomerase activity
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
10.58 – 10.7 Mb

Chr 14:
64.48 – 64.54 Mb

PubMed search

[1]

[2]

PIN2-interacting protein 1, also known as PINX1, is a human gene.^[1]

Interactions

PINX1 has been shown to interact with MCRS1,^[2] TERF1^[3] and Telomerase reverse transcriptase.^[3]

References

^ "Entrez Gene: PINX1 PIN2-interacting protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54984.
^ Song, Hai; Li Yiliang, Chen Guoyuan, Xing Zhen, Zhao Jing, Yokoyama Kazunari K, Li Tsaiping, Zhao Mujun (Apr. 2004). "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length". Biochem. Biophys. Res. Commun. (United States) 316 (4): 1116–23. doi:10.1016/j.bbrc.2004.02.166. ISSN 0006-291X. PMID 15044100.
^ ^a ^b Zhou, X Z; Lu K P (Nov. 2001). "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor". Cell (United States) 107 (3): 347–59. doi:10.1016/S0092-8674(01)00538-4. ISSN 0092-8674. PMID 11701125.

Liao C, Zhao M, Song H et al. (2000). "Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma". Hepatology 32 (4 Pt 1): 721–7. doi:10.1053/jhep.2000.17967. PMID 11003615.
Zhou XZ, Lu KP (2001). "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor". Cell 107 (3): 347–59. doi:10.1016/S0092-8674(01)00538-4. PMID 11701125.
Guglielmi B, Werner M (2002). "The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition". J. Biol. Chem. 277 (38): 35712–9. doi:10.1074/jbc.M205526200. PMID 12107183.
Liao C, Zhao MJ, Zhao J et al. (2003). "Over-expression of LPTS-L in hepatocellular carcinoma cell line SMMC-7721 induces crisis". World J. Gastroenterol. 8 (6): 1050–2. PMID 12439923.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Liao C, Zhao MJ, Zhao J et al. (2003). "Mutation analysis of novel human liver-related putative tumor suppressor gene in hepatocellular carcinoma". World J. Gastroenterol. 9 (1): 89–93. PMID 12508358.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wang S, Liao C, Li T, Zhao M (2004). "Cloning and characterization of the promoter region of human LPTS/PinX1 gene". Biochim. Biophys. Acta 1676 (3): 261–5. doi:10.1016/j.bbaexp.2003.12.002. PMID 14984932.
Song H, Li Y, Chen G et al. (2004). "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length". Biochem. Biophys. Res. Commun. 316 (4): 1116–23. doi:10.1016/j.bbrc.2004.02.166. PMID 15044100.
Banik SS, Counter CM (2005). "Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR". J. Biol. Chem. 279 (50): 51745–8. doi:10.1074/jbc.M408131200. PMID 15381700.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Kondo T, Oue N, Mitani Y et al. (2005). "Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma". Oncogene 24 (1): 157–64. doi:10.1038/sj.onc.1207832. PMID 15637589.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.

PINX1

Interactions

References

Further reading