PICK1
PRKCA-binding protein is a protein that in humans is encoded by the PICK1 gene.[1][2]
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.[3]
Interactions
PICK1 has been shown to interact with HER2/neu,[4] ACCN2,[5][6] Metabotropic glutamate receptor 7,[7] BNC1,[6] Metabotropic glutamate receptor 3,[8] GRIA4,[8] Dopamine transporter,[9] GRIK1,[10] GRIK2,[10] GRIK3,[8] GRIA2[8] and GRIA3.[8]
References
- ^ Dev KK, Nishimune A, Henley JM, Nakanishi S (Jul 1999). "The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits". Neuropharmacology 38 (5): 635–44. doi:10.1016/S0028-3908(98)00230-5. PMID 10340301.
- ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- ^ "Entrez Gene: PICK1 protein interacting with PRKCA 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9463.
- ^ Jaulin-Bastard, F; Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, Borg J P (May. 2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. (United States) 276 (18): 15256–63. doi:10.1074/jbc.M010032200. ISSN 0021-9258. PMID 11278603.
- ^ Leonard, A Soren; Yermolaieva Olena, Hruska-Hageman Alesia, Askwith Candice C, Price Margaret P, Wemmie John A, Welsh Michael J (Feb. 2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (4): 2029–34. doi:10.1073/pnas.252782799. ISSN 0027-8424. PMC 149953. PMID 12578970. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=149953.
- ^ a b Hruska-Hageman, Alesia M; Wemmie John A, Price Margaret P, Welsh Michael J (Feb. 2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. (England) 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. ISSN 0264-6021. PMC 1222326. PMID 11802773. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222326.
- ^ Dev, K K; Nakajima Y, Kitano J, Braithwaite S P, Henley J M, Nakanishi S (Oct. 2000). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. (UNITED STATES) 20 (19): 7252–7. PMID 11007882.
- ^ a b c d e Hirbec, Hélène; Perestenko Olga, Nishimune Atsushi, Meyer Guido, Nakanishi Shigetada, Henley Jeremy M, Dev Kumlesh K (May. 2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. (United States) 277 (18): 15221–4. doi:10.1074/jbc.C200112200. ISSN 0021-9258. PMID 11891216.
- ^ Torres, G E; Yao W D, Mohn A R, Quan H, Kim K M, Levey A I, Staudinger J, Caron M G (Apr. 2001). "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1". Neuron (United States) 30 (1): 121–34. doi:10.1016/S0896-6273(01)00267-7. ISSN 0896-6273. PMID 11343649.
- ^ a b Hirbec, Hélène; Francis Joanna C, Lauri Sari E, Braithwaite Steven P, Coussen Françoise, Mulle Christophe, Dev Kumlesh K, Coutinho Victoria, Meyer Guido, Isaac John T R, Collingridge Graham L, Henley Jeremy M, Couthino Victoria (Feb. 2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron (United States) 37 (4): 625–38. doi:10.1016/S0896-6273(02)01191-1. ISSN 0896-6273. PMID 12597860.
Further reading
- Collingridge GL, Isaac JT (2003). "Functional roles of protein interactions with AMPA and kainate receptors". Neurosci. Res. 47 (1): 3–15. doi:10.1016/S0168-0102(03)00160-3. PMID 12941441.
- Xu J, Xia J (2006). "Structure and function of PICK1". Neurosignals 15 (4): 190–201. doi:10.1159/000098482. PMID 17215589.
- Staudinger J, Zhou J, Burgess R et al. (1995). "PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system". J. Cell Biol. 128 (3): 263–71. doi:10.1083/jcb.128.3.263. PMC 2120344. PMID 7844141. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120344.
- Staudinger J, Lu J, Olson EN (1998). "Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha". J. Biol. Chem. 272 (51): 32019–24. doi:10.1074/jbc.272.51.32019. PMID 9405395.
- Xia J, Zhang X, Staudinger J, Huganir RL (1999). "Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1". Neuron 22 (1): 179–87. doi:10.1016/S0896-6273(00)80689-3. PMID 10027300.
- Torres R, Firestein BL, Dong H et al. (1999). "PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands". Neuron 21 (6): 1453–63. doi:10.1016/S0896-6273(00)80663-7. PMID 9883737.
- Takeya R, Takeshige K, Sumimoto H (2000). "Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors". Biochem. Biophys. Res. Commun. 267 (1): 149–55. doi:10.1006/bbrc.1999.1932. PMID 10623590.
- Cowan CA, Yokoyama N, Bianchi LM et al. (2000). "EphB2 guides axons at the midline and is necessary for normal vestibular function". Neuron 26 (2): 417–30. doi:10.1016/S0896-6273(00)81174-5. PMID 10839360.
- Dev KK, Nakajima Y, Kitano J et al. (2001). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. 20 (19): 7252–7. PMID 11007882.
- Lin WJ, Chang YF, Wang WL, Huang CY (2001). "Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1". Biochem. J. 354 (Pt 3): 635–43. doi:10.1042/0264-6021:3540635. PMC 1221695. PMID 11237868. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221695.
- Jaulin-Bastard F, Saito H, Le Bivic A et al. (2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. 276 (18): 15256–63. doi:10.1074/jbc.M010032200. PMID 11278603.
- Torres GE, Yao WD, Mohn AR et al. (2001). "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1". Neuron 30 (1): 121–34. doi:10.1016/S0896-6273(01)00267-7. PMID 11343649.
- Lin SH, Arai AC, Wang Z et al. (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering". Mol. Pharmacol. 60 (5): 916–23. PMID 11641419.
- Duggan A, Garcia-Anoveros J, Corey DP (2002). "The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons". J. Biol. Chem. 277 (7): 5203–8. doi:10.1074/jbc.M104748200. PMID 11739374.
- Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. PMC 1222326. PMID 11802773. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222326.
- Hirbec H, Perestenko O, Nishimune A et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
- Perroy J, El Far O, Bertaso F et al. (2002). "PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7". EMBO J. 21 (12): 2990–9. doi:10.1093/emboj/cdf313. PMC 126066. PMID 12065412. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126066.
- Jansen A, Nässel D, Madsen K et al. (2009). "PICK1 expression in the Drosophila nervous system primarily occurs in the nervous system". J. Comp. Neurol. 517 (3): 313–322. doi:10.1002/cne.22155. PMID 19757495.
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PDB gallery
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2gzv: The cystal structure of the PDZ domain of human PICK1 (CASP TARGET)
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External links