PHACTR3
Phosphatase and actin regulator 3 is an enzyme that in humans is encoded by the PHACTR3 gene.[1][2]
The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.[2]
Interactions
PHACTR3 has been shown to interact with PPP1CA.[3]
References
- ^ Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P (May 2004). "Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins". Proc Natl Acad Sci U S A 101 (18): 7187–92. doi:10.1073/pnas.0401673101. PMC 406487. PMID 15107502. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=406487.
- ^ a b "Entrez Gene: PHACTR3 phosphatase and actin regulator 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116154.
- ^ Sagara, Junji; Higuchi Tsukasa, Hattori Yukiko, Moriya Mie, Sarvotham Haritha, Shima Hiroshi, Shirato Haruki, Kikuchi Kunimi, Taniguchi Shunichiro (Nov. 2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. (United States) 278 (46): 45611–9. doi:10.1074/jbc.M305227200. ISSN 0021-9258. PMID 12925532.
Further reading
- Worch S, Fiedler E, Hansmann I, Schlote D (2006). "Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human.". Cytogenet. Genome Res. 115 (1): 23–9. doi:10.1159/000094797. PMID 16974080.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Sagara J, Higuchi T, Hattori Y, et al. (2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure.". J. Biol. Chem. 278 (46): 45611–9. doi:10.1074/jbc.M305227200. PMID 12925532.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.