PFKFB4

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

PDB rendering based on 3bif.

Available structures
PDB	3bif, 1bif, 2bif

Identifiers

Symbol

PFKFB4

External IDs

OMIM: 605320 MGI: 2687284 HomoloGene: 48288 GeneCards: PFKFB4 Gene

EC number

2.7.1.105

Gene Ontology
Molecular function	• fructose-2,6-bisphosphate 2-phosphatase activity • ATP binding • identical protein binding • kinase activity • catalytic activity • 6-phosphofructo-2-kinase activity • hydrolase activity • nucleotide binding • transferase activity
Cellular component	• cellular_component • cytosol
Biological process	• fructose 2,6-bisphosphate metabolic process • metabolic process • fructose metabolic process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
48.53 – 48.57 Mb

Chr 9:
108.89 – 108.93 Mb

PubMed search

[1]

[2]

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 also known as PFKFB4 is a enzyme which in humans is encoded by the PFKFB4 gene.^[1]^[2]

Function

The bifunctional 6-phosphofructo-2-kinase (EC 2.7.1.105)/fructose-2,6-bisphosphatase (EC 3.1.3.46) (PFKFB) regulates the steady-state concentration of fructose 2,6-bisphosphate, an activator of a key regulatory enzyme of glycolysis, phosphofructokinase.

References

^ Sakai A, Kato M, Fukasawa M, Ishiguro M, Furuya E, Sakakibara R (March 1996). "Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta". J. Biochem. 119 (3): 506–11. PMID 8830046. http://jb.oxfordjournals.org/cgi/content/abstract/119/3/506.
^ Manzano A, Pérez JX, Nadal M, Estivill X, Lange A, Bartrons R (March 1999). "Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene". Gene 229 (1-2): 83–9. doi:10.1016/S0378-1119(99)00037-2. PMID 10095107.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Pilkis SJ, Claus TH, Kurland IJ, Lange AJ (1995). "6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme.". Annu. Rev. Biochem. 64: 799–835. doi:10.1146/annurev.bi.64.070195.004055. PMID 7574501.
GÃ³mez M, Manzano A, Navarro-SabatÃ© A, et al. (2005). "Specific expression of pfkfb4 gene in spermatogonia germ cells and analysis of its 5'-flanking region.". FEBS Lett. 579 (2): 357–62. doi:10.1016/j.febslet.2004.11.096. PMID 15642344.
Minchenko OH, Ochiai A, Opentanova IL, et al. (2005). "Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors.". Biochimie 87 (11): 1005–10. doi:10.1016/j.biochi.2005.04.007. PMID 15925437.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Minchenko O, Opentanova I, Minchenko D, et al. (2004). "Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation.". FEBS Lett. 576 (1-2): 14–20. doi:10.1016/j.febslet.2004.08.053. PMID 15474002.
Bobarykina AY, Minchenko DO, Opentanova IL, et al. (2006). "Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers.". Acta Biochim. Pol. 53 (4): 789–99. PMID 17143338.