PFKFB3

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

PDB rendering based on 2axn.

Available structures
PDB	2AXN, 2DWO, 2DWP, 2I1V

Identifiers

Symbols

PFKFB3; FLJ37326; IPFK2; PFK2

External IDs

OMIM: 605319 MGI: 2181202 HomoloGene: 88708 GeneCards: PFKFB3 Gene

EC number

2.7.1.105

Gene Ontology
Molecular function	• nucleotide binding • 6-phosphofructo-2-kinase activity • fructose-2,6-bisphosphate 2-phosphatase activity • protein binding • ATP binding • kinase activity • transferase activity • hydrolase activity • identical protein binding
Cellular component	• cytosol
Biological process	• carbohydrate metabolic process • fructose 2,6-bisphosphate metabolic process • glucose metabolic process • glycolysis • brain development
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
6.19 – 6.28 Mb

Chr 2:
11.39 – 11.42 Mb

PubMed search

[1]

[2]

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 is an enzyme that in humans is encoded by the PFKFB3 gene.^[1]^[2]^[3]

References

^ Nicholl J, Hamilton JA, Sutherland GR, Sutherland RL, Watts CK (Jun 1997). "The third human isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) map position 10p14-p15". Chromosome Res 5 (2): 150. PMID 9146922.
^ Manzano A, Rosa JL, Ventura F, Perez JX, Nadal M, Estivill X, Ambrosio S, Gil J, Bartrons R (Mar 1999). "Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6-bisphosphatase gene (PFKFB3)". Cytogenet Cell Genet 83 (3–4): 214–7. doi:10.1159/000015181. PMID 10072580.
^ "Entrez Gene: PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5209.

Sakai A, Kato M, Fukasawa M, et al. (1996). "Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta". J. Biochem. 119 (3): 506–11. PMID 8830046.
Hamilton JA, Callaghan MJ, Sutherland RL, Watts CK (1997). "Identification of PRG1, a novel progestin-responsive gene with sequence homology to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase". Mol. Endocrinol. 11 (4): 490–502. doi:10.1210/me.11.4.490. PMID 9092801.
Sakakibara R, Kato M, Okamura N, et al. (1997). "Characterization of a human placental fructose-6-phosphate, 2-kinase/fructose-2,6-bisphosphatase". J. Biochem. 122 (1): 122–8. PMID 9276680.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
Fukasawa M, Takayama E, Shinomiya N, et al. (2000). "Identification of the promoter region of human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene". Biochem. Biophys. Res. Commun. 267 (3): 703–8. doi:10.1006/bbrc.1999.2022. PMID 10673355.
Kessler R, Eschrich K (2001). "Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain". Brain Res. Mol. Brain Res. 87 (2): 190–5. doi:10.1016/S0169-328X(01)00014-6. PMID 11245921.
Navarro-Sabaté A, Manzano A, Riera L, et al. (2001). "The human ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene (PFKFB3): promoter characterization and genomic structure". Gene 264 (1): 131–8. doi:10.1016/S0378-1119(00)00591-6. PMID 11245987.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Riera L, Obach M, Navarro-Sabaté A, et al. (2003). "Regulation of ubiquitous 6-phosphofructo-2-kinase by the ubiquitin-proteasome proteolytic pathway during myogenic C2C12 cell differentiation". FEBS Lett. 550 (1–3): 23–9. doi:10.1016/S0014-5793(03)00808-1. PMID 12935880.
Obach M, Navarro-Sabaté A, Caro J, et al. (2005). "6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia". J. Biol. Chem. 279 (51): 53562–70. doi:10.1074/jbc.M406096200. PMID 15466858.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Manes NP, El-Maghrabi MR (2005). "The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate". Arch. Biochem. Biophys. 438 (2): 125–36. doi:10.1016/j.abb.2005.04.011. PMID 15896703.
Minchenko OH, Ogura T, Opentanova IL, et al. (2006). "Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation". Mol. Cell. Biochem. 280 (1–2): 227–34. doi:10.1007/s11010-005-8009-6. PMID 16311927.