PEX3

Peroxisomal biogenesis factor 3

Identifiers

PEX3; DKFZp686N14184; FLJ13531; TRG18

External IDs

OMIM: 603164 MGI: 1929646 HomoloGene: 2691 GeneCards: PEX3 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• peroxisome • peroxisome • peroxisomal membrane • integral to peroxisomal membrane • membrane • integral to membrane
Biological process	• peroxisome organization • peroxisome membrane biogenesis • protein import into peroxisome membrane • transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
143.77 – 143.81 Mb

Chr 10:
13.24 – 13.27 Mb

PubMed search

[1]

[2]

Peroxisomal biogenesis factor 3 is a protein that in humans is encoded by the PEX3 gene.^[1]^[2]

1 Interactions
2 References
3 Further reading
4 External Links

Interactions

PEX3 has been shown to interact with PEX19.^[3]^[4]^[5]^[6]

References

^ Kammerer S, Holzinger A, Welsch U, Roscher AA (Jul 1998). "Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p". FEBS Lett 429 (1): 53–60. doi:10.1016/S0014-5793(98)00557-2. PMID 9657383.
^ "Entrez Gene: PEX3 peroxisomal biogenesis factor 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8504.
^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
^ Mayerhofer, Peter U; Kattenfeld Tanja, Roscher Adelbert A, Muntau Ania C (Mar. 2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochem. Biophys. Res. Commun. (United States) 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. ISSN 0006-291X. PMID 11883941.
^ Sacksteder, K A; Jones J M, South S T, Li X, Liu Y, Gould S J (Mar. 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". J. Cell Biol. (UNITED STATES) 148 (5): 931–44. doi:10.1083/jcb.148.5.931. ISSN 0021-9525. PMC 2174547. PMID 10704444. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174547.
^ Fransen, M; Wylin T, Brees C, Mannaerts G P, Van Veldhoven P P (Jul. 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Mol. Cell. Biol. (United States) 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN 0270-7306. PMC 87101. PMID 11390669. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87101.

South ST, Gould SJ (1999). "Peroxisome synthesis in the absence of preexisting peroxisomes.". J. Cell Biol. 144 (2): 255–66. doi:10.1083/jcb.144.2.255. PMC 2132891. PMID 9922452. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132891.
Soukupova M, Sprenger C, Gorgas K, et al. (1999). "Identification and characterization of the human peroxin PEX3.". Eur. J. Cell Biol. 78 (6): 357–74. PMID 10430017.
Muntau AC, Holzinger A, Mayerhofer PU, et al. (2000). "The human PEX3 gene encoding a peroxisomal assembly protein: genomic organization, positional mapping, and mutation analysis in candidate phenotypes.". Biochem. Biophys. Res. Commun. 268 (3): 704–10. doi:10.1006/bbrc.2000.2193. PMID 10679269.
Sacksteder KA, Jones JM, South ST, et al. (2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174547.
Ghaedi K, Tamura S, Okumoto K, et al. (2000). "The peroxin pex3p initiates membrane assembly in peroxisome biogenesis.". Mol. Biol. Cell 11 (6): 2085–102. PMC 14905. PMID 10848631. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=14905.
Muntau AC, Mayerhofer PU, Paton BC, et al. (2000). "Defective peroxisome membrane synthesis due to mutations in human PEX3 causes Zellweger syndrome, complementation group G.". Am. J. Hum. Genet. 67 (4): 967–75. doi:10.1086/303071. PMC 1287898. PMID 10958759. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1287898.
Ghaedi K, Honsho M, Shimozawa N, et al. (2000). "PEX3 is the causal gene responsible for peroxisome membrane assembly-defective Zellweger syndrome of complementation group G.". Am. J. Hum. Genet. 67 (4): 976–81. doi:10.1086/303086. PMC 1287899. PMID 10968777. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1287899.
Fransen M, Wylin T, Brees C, et al. (2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87101.
Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly.". Biochem. Biophys. Res. Commun. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941.
Fransen M, Brees C, Ghys K, et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay.". Mol. Cell Proteomics 1 (3): 243–52. doi:10.1074/mcp.M100025-MCP200. PMID 12096124.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Muntau AC, Roscher AA, Kunau WH, Dodt G (2003). "The interaction between human PEX3 and PEX19 characterized by fluorescence resonance energy transfer (FRET) analysis.". Eur. J. Cell Biol. 82 (7): 333–42. doi:10.1078/0171-9335-00325. PMID 12924628.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Muntau AC, Roscher AA, Kunau WH, Dodt G (2004). "Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET).". Adv. Exp. Med. Biol. 544: 221–4. PMID 14713233.
Fang Y, Morrell JC, Jones JM, Gould SJ (2004). "PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins.". J. Cell Biol. 164 (6): 863–75. doi:10.1083/jcb.200311131. PMC 2172291. PMID 15007061. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172291.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Matsuzono Y, Matsuzaki T, Fujiki Y (2007). "Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation.". J. Cell. Sci. 119 (Pt 17): 3539–50. doi:10.1242/jcs.03100. PMID 16895967.

PEX3

Contents

Interactions

References

Further reading

External Links