PEX19

Peroxisomal biogenesis factor 19

Rendering based on PDB 2W85.

Available structures
PDB	2W85, 2WL8, 3MK4

Identifiers

Symbols

PEX19; D1S2223E; FLJ55296; HK33; PMP1; PMPI; PXF; PXMP1

External IDs

OMIM: 600279 MGI: 1334458 HomoloGene: 37696 GeneCards: PEX19 Gene

Gene Ontology
Molecular function	• protein binding • protein N-terminus binding
Cellular component	• nucleus • cytoplasm • cytoplasm • cytoplasm • peroxisome • peroxisomal membrane • cytosol • membrane • integral to membrane • brush border membrane
Biological process	• protein targeting to peroxisome • peroxisome organization • peroxisome organization • peroxisome membrane biogenesis • transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
160.19 – 160.26 Mb

Chr 1:
174.06 – 174.07 Mb

PubMed search

[1]

[2]

Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the PEX19 gene.^[1]^[2]^[3]

1 Interactions
2 References
3 Further reading
4 External Links

Interactions

PEX19 has been shown to interact with PEX10,^[4]^[5] PEX12,^[4]^[5] PEX13,^[4]^[5] ABCD3,^[6]^[7]^[4]^[8] ABCD1,^[6]^[7] PEX3,^[9]^[6]^[4]^[5] ABCD2,^[6]^[7] PEX11B^[4]^[5] and PEX16.^[5]

References

^ Kammerer S, Arnold N, Gutensohn W, Mewes HW, Kunau WH, Hofler G, Roscher AA, Braun A (Nov 1997). "Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein". Genomics 45 (1): 200–10. doi:10.1006/geno.1997.4914. PMID 9339377.
^ Matsuzono Y, Kinoshita N, Tamura S, Shimozawa N, Hamasaki M, Ghaedi K, Wanders RJ, Suzuki Y, Kondo N, Fujiki Y (Apr 1999). "Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly". Proc Natl Acad Sci U S A 96 (5): 2116–21. doi:10.1073/pnas.96.5.2116. PMC 26746. PMID 10051604. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26746.
^ "Entrez Gene: PEX19 peroxisomal biogenesis factor 19". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5824.
^ ^a ^b ^c ^d ^e ^f Sacksteder, K A; Jones J M, South S T, Li X, Liu Y, Gould S J (Mar. 2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. (UNITED STATES) 148 (5): 931–44. doi:10.1083/jcb.148.5.931. ISSN 0021-9525. PMC 2174547. PMID 10704444. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174547.
^ ^a ^b ^c ^d ^e ^f Fransen, M; Wylin T, Brees C, Mannaerts G P, Van Veldhoven P P (Jul. 2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. (United States) 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN 0270-7306. PMC 87101. PMID 11390669. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87101.
^ ^a ^b ^c ^d Mayerhofer, Peter U; Kattenfeld Tanja, Roscher Adelbert A, Muntau Ania C (Mar. 2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochem. Biophys. Res. Commun. (United States) 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. ISSN 0006-291X. PMID 11883941.
^ ^a ^b ^c Gloeckner, C J; Mayerhofer P U, Landgraf P, Muntau A C, Holzinger A, Gerber J K, Kammerer S, Adamski J, Roscher A A (Apr. 2000). "Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p". Biochem. Biophys. Res. Commun. (UNITED STATES) 271 (1): 144–50. doi:10.1006/bbrc.2000.2572. ISSN 0006-291X. PMID 10777694.
^ Biermanns, M; Gärtner J (Jul. 2001). "Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes". Biochem. Biophys. Res. Commun. (United States) 285 (3): 649–55. doi:10.1006/bbrc.2001.5220. ISSN 0006-291X. PMID 11453642.
^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Braun A, Kammerer S, Weissenhorn W et al. (1994). "Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1". Gene 146 (2): 291–5. doi:10.1016/0378-1119(94)90308-5. PMID 8076834.
Götte K, Girzalsky W, Linkert M et al. (1998). "Pex19p, a Farnesylated Protein Essential for Peroxisome Biogenesis". Mol. Cell. Biol. 18 (1): 616–28. PMC 121529. PMID 9418908. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=121529.
Sacksteder KA, Jones JM, South ST et al. (2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174547.
Gloeckner CJ, Mayerhofer PU, Landgraf P et al. (2000). "Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p". Biochem. Biophys. Res. Commun. 271 (1): 144–50. doi:10.1006/bbrc.2000.2572. PMID 10777694.
Sugihara T, Kaul SC, Kato J et al. (2001). "Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway". J. Biol. Chem. 276 (22): 18649–52. doi:10.1074/jbc.C100011200. PMID 11259404.
Fransen M, Wylin T, Brees C et al. (2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87101.
Biermanns M, Gärtner J (2001). "Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes". Biochem. Biophys. Res. Commun. 285 (3): 649–55. doi:10.1006/bbrc.2001.5220. PMID 11453642.
Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochem. Biophys. Res. Commun. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941.
Fransen M, Brees C, Ghys K et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Mol. Cell Proteomics 1 (3): 243–52. doi:10.1074/mcp.M100025-MCP200. PMID 12096124.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ito M, Iidawa S, Izuka M et al. (2004). "Interaction of a farnesylated protein with renal type IIa Na/Pi co-transporter in response to parathyroid hormone and dietary phosphate". Biochem. J. 377 (Pt 3): 607–16. doi:10.1042/BJ20031223. PMC 1223893. PMID 14558883. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223893.
Jones JM, Morrell JC, Gould SJ (2004). "PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins". J. Cell Biol. 164 (1): 57–67. doi:10.1083/jcb.200304111. PMC 2171958. PMID 14709540. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2171958.
Muntau AC, Roscher AA, Kunau WH, Dodt G (2004). "Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET)". Adv. Exp. Med. Biol. 544: 221–4. PMID 14713233.
Fransen M, Vastiau I, Brees C et al. (2004). "Potential role for Pex19p in assembly of PTS-receptor docking complexes". J. Biol. Chem. 279 (13): 12615–24. doi:10.1074/jbc.M304941200. PMID 14715663.
Fang Y, Morrell JC, Jones JM, Gould SJ (2004). "PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins". J. Cell Biol. 164 (6): 863–75. doi:10.1083/jcb.200311131. PMC 2172291. PMID 15007061. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172291.
Colland F, Jacq X, Trouplin V et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
Shibata H, Kashiwayama Y, Imanaka T, Kato H (2004). "Domain architecture and activity of human Pex19p, a chaperone-like protein for intracellular trafficking of peroxisomal membrane proteins". J. Biol. Chem. 279 (37): 38486–94. doi:10.1074/jbc.M402204200. PMID 15252024.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.

PEX19

Contents

Interactions

References

Further reading

External Links