PEX1

Peroxisomal biogenesis factor 1
Identifiers
Symbols PEX1; ZWS; ZWS1
External IDs OMIM602136 MGI1918632 HomoloGene27006 GeneCards: PEX1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5189 71382
Ensembl ENSG00000127980 ENSMUSG00000005907
UniProt O43933 n/a
RefSeq (mRNA) NM_000466 NM_027777.1
RefSeq (protein) NP_000457 NP_082053.1
Location (UCSC) Chr 7:
92.12 – 92.16 Mb
Chr 5:
3.6 – 3.64 Mb
PubMed search [1] [2]

Peroxisome biogenesis factor 1, also known as PEX1, is a protein which in humans is encoded by the PEX1 gene.[1]

This gene encodes a member of the AAA protein family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome.[1]

Contents

Interactions

PEX1 has been shown to interact with PEX6[2][3] and PEX26.[4]

References

  1. ^ a b "Entrez Gene: PEX1 peroxisome biogenesis factor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5189. 
  2. ^ Tamura, S; Shimozawa N, Suzuki Y, Tsukamoto T, Osumi T, Fujiki Y (Apr. 1998). "A cytoplasmic AAA family peroxin, Pex1p, interacts with Pex6p". Biochem. Biophys. Res. Commun. (UNITED STATES) 245 (3): 883–6. doi:10.1006/bbrc.1998.8522. ISSN 0006-291X. PMID 9588209. 
  3. ^ Geisbrecht, B V; Collins C S, Reuber B E, Gould S J (Jul. 1998). "Disruption of a PEX1-PEX6 interaction is the most common cause of the neurologic disorders Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile Refsum disease". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (15): 8630–5. doi:10.1073/pnas.95.15.8630. ISSN 0027-8424. PMC 21127. PMID 9671729. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21127. 
  4. ^ Matsumoto, Naomi; Tamura Shigehiko, Fujiki Yukio (May. 2003). "The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes". Nat. Cell Biol. (England) 5 (5): 454–60. doi:10.1038/ncb982. ISSN 1465-7392. PMID 12717447. 

Further reading

External Links