PDIA3

protein disulfide isomerase family A, member 3
Identifiers
Symbol PDIA3
Alt. symbols GRP58
Entrez 2923
HUGO 4606
OMIM 602046
RefSeq NM_005313
UniProt P30101
Other data
EC number 5.3.4.1
Locus Chr. 15 q15

Protein disulfide isomerase family A, member 3 (PDIA3) also known as glucose-regulated protein, 58-kD(GRP58) is an isomerase enzyme.[1][2][3]

Contents

Function

The PDIA3 protein has protein disulfide isomerase activity.[3] PDIA3 is also part of the major histocompatibility complex (MHC) class I peptide-loading complex, which is essential for formation of the final antigen conformation and export from the endoplasmic reticulum to the cell surface.[4]

See also

References

  1. ^ Bourdi M, Demady D, Martin JL, Jabbour SK, Martin BM, George JW, Pohl LR (November 1995). "cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase". Archives of biochemistry and biophysics 323 (2): 397–403. doi:10.1006/abbi.1995.0060. PMID 7487104. 
  2. ^ Hirano N, Shibasaki F, Sakai R, Tanaka T, Nishida J, Yazaki Y, Takenawa T, Hirai H' (November 1995). "Molecular cloning of the human glucose-regulated protein ERp57/GRP58, a thiol-dependent reductase. Identification of its secretory form and inducible expression by the oncogenic transformation". European journal of biochemistry / FEBS 234 (1): 336–42. doi:10.1111/j.1432-1033.1995.336_c.x. PMID 8529662. 
  3. ^ a b Koivunen P, Helaakoski T, Annunen P, Veijola J, Räisänen S, Pihlajaniemi T, Kivirikko KI' (June 1996). "ERp60 does not substitute for protein disulphide isomerase as the beta-subunit of prolyl 4-hydroxylase". The Biochemical journal. 316 ( Pt 2): 599–605. PMC 1217390. PMID 8687406. http://www.biochemj.org/bj/316/0599/bj3160599.htm. 
  4. ^ Garbi N, Tanaka S, Momburg F, Hämmerling GJ (January 2006). "Impaired assembly of the major histocompatibility complex class I peptide-loading complex in mice deficient in the oxidoreductase ERp57". Nature immunology 7 (1): 93–102. doi:10.1038/ni1288. PMID 16311600. 

External links

Isomerases: intramolecular oxidoreductases (EC 5.3)
5.3.1: Aldoses/Ketoses
5.3.2: Keto/Enol
5.3.3: C=C
5.3.4: S-S
5.3.99: other
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6