PDE8B

Phosphodiesterase 8B

Identifiers

PDE8B; ADSD; FLJ11212; PPNAD3

External IDs

OMIM: 603390 MGI: 2443999 HomoloGene: 2758 GeneCards: PDE8B Gene

3.1.4.17

Gene Ontology
Molecular function	• two-component response regulator activity • 3',5'-cyclic-nucleotide phosphodiesterase activity • 3',5'-cyclic-AMP phosphodiesterase activity • phosphoric diester hydrolase activity • hydrolase activity • metal ion binding
Cellular component	• cellular_component • cytosol
Biological process	• regulation of transcription, DNA-dependent • cyclic nucleotide metabolic process • negative regulation of insulin secretion
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
76.51 – 76.73 Mb

Chr 13:
95.79 – 96.02 Mb

PubMed search

[1]

[2]

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B is an enzyme that in humans is encoded by the PDE8B gene.^[1]^[2]

References

^ Hayashi M, Matsushima K, Ohashi H, Tsunoda H, Murase S, Kawarada Y, Tanaka T (Nov 1998). "Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase". Biochem Biophys Res Commun 250 (3): 751–6. doi:10.1006/bbrc.1998.9379. PMID 9784418.
^ "Entrez Gene: PDE8B phosphodiesterase 8B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8622.

Dias Neto E, Correa RG, Verjovski-Almeida S et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16267.
Persani L, Borgato S, Lania A et al. (2001). "Relevant cAMP-specific phosphodiesterase isoforms in human pituitary: effect of Gs(alpha) mutations". J. Clin. Endocrinol. Metab. 86 (8): 3795–800. doi:10.1210/jc.86.8.3795. PMID 11502813.
Hayashi M, Shimada Y, Nishimura Y et al. (2002). "Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene". Biochem. Biophys. Res. Commun. 297 (5): 1253–8. doi:10.1016/S0006-291X(02)02371-9. PMID 12372422.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gamanuma M, Yuasa K, Sasaki T et al. (2003). "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans". Cell. Signal. 15 (6): 565–74. doi:10.1016/S0898-6568(02)00146-8. PMID 12681444.
Pérez-Torres S, Cortés R, Tolnay M et al. (2003). "Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer's disease brains examined by in situ hybridization". Exp. Neurol. 182 (2): 322–34. doi:10.1016/S0014-4886(03)00042-6. PMID 12895443.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.

PDE8B

References

Further reading