cAMP-specific 3',5'-cyclic phosphodiesterase 4A is an enzyme that in humans is encoded by the PDE4Agene.[1][2]
Interactions
References
^Milatovich A, Bolger G, Michaeli T, Francke U (Jul 1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somat Cell Mol Genet20 (2): 75–86. doi:10.1007/BF02290677. PMID8009369.
Houslay MD, Schafer P, Zhang KY (2006). "Keynote review: phosphodiesterase-4 as a therapeutic target.". Drug Discov. Today10 (22): 1503–19. doi:10.1016/S1359-6446(05)03622-6. PMID16257373.
Zhang KY, Ibrahim PN, Gillette S, Bollag G (2006). "Phosphodiesterase-4 as a potential drug target.". Expert Opin. Ther. Targets9 (6): 1283–305. doi:10.1517/14728222.9.6.1283. PMID16300476.
Sullivan M, Egerton M, Shakur Y, et al. (1995). "Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)". Cell. Signal.6 (7): 793–812. doi:10.1016/0898-6568(94)00039-5. PMID7888306.
Huston E, Pooley L, Julien P, et al. (1997). "The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram". J. Biol. Chem.271 (49): 31334–44. doi:10.1074/jbc.271.49.31334. PMID8940140.
McPhee I, Yarwood SJ, Scotland G, et al. (1999). "Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition". J. Biol. Chem.274 (17): 11796–810. doi:10.1074/jbc.274.17.11796. PMID10206997.
Zhou L, Thompson WJ, Potter DE (1999). "Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells". Invest. Ophthalmol. Vis. Sci.40 (8): 1745–52. PMID10393044.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J.15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID11156964.
Rena G, Begg F, Ross A, et al. (2001). "Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10". Mol. Pharmacol.59 (5): 996–1011. PMID11306681.
Lario PI, Bobechko B, Bateman K, et al. (2001). "Purification and characterization of the human PDE4A catalytic domain (PDE4A330-723) expressed in Sf9 cells". Arch. Biochem. Biophys.394 (1): 54–60. doi:10.1006/abbi.2001.2513. PMID11566027.
Moon E, Lee R, Near R, et al. (2002). "Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia". Clin. Cancer Res.8 (2): 589–95. PMID11839681.
Laliberté F, Liu S, Gorseth E, et al. (2002). "In vitro PKA phosphorylation-mediated human PDE4A4 activation". FEBS Lett.512 (1–3): 205–8. doi:10.1016/S0014-5793(02)02259-7. PMID11852080.
Baillie GS, Huston E, Scotland G, et al. (2002). "TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid". J. Biol. Chem.277 (31): 28298–309. doi:10.1074/jbc.M108353200. PMID11994273.
Pryzwansky KB, Madden VJ (2004). "Type 4A cAMP-specific phosphodiesterase is stored in granules of human neutrophils and eosinophils". Cell Tissue Res.312 (3): 301–11. doi:10.1007/s00441-003-0728-y. PMID12764607.
PDB gallery
1loi: N-TERMINAL SPLICE REGION OF RAT C-AMP PHOSPHODIESTERASE, NMR, 7 STRUCTURES