PDE2A

Phosphodiesterase 2A, cGMP-stimulated

PDB rendering based on 1mc0.

Available structures
PDB	1Z1L, 3IBJ, 3ITM, 3ITU

Identifiers

Symbols

PDE2A; PDE2A1; PED2A4

External IDs

OMIM: 602658 MGI: 2446107 HomoloGene: 1952 GeneCards: PDE2A Gene

EC number

3.1.4.17

Gene Ontology
Molecular function	• nucleotide binding • 3',5'-cyclic-AMP phosphodiesterase activity • cGMP-stimulated cyclic-nucleotide phosphodiesterase activity • protein binding • phosphoric diester hydrolase activity • hydrolase activity • cAMP binding • cGMP binding • protein homodimerization activity • metal ion binding • 3',5'-cyclic-GMP phosphodiesterase activity
Cellular component	• cytosol • cytosol • membrane • membrane raft
Biological process	• cAMP catabolic process • signal transduction • blood coagulation • platelet activation • cGMP catabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
72.29 – 72.39 Mb

Chr 7:
108.57 – 108.66 Mb

PubMed search

[1]

[2]

cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.^[1]^[2]

References

^ Rosman GJ, Martins TJ, Sonnenburg WK, Beavo JA, Ferguson K, Loughney K (Aug 1997). "Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase". Gene 191 (1): 89–95. doi:10.1016/S0378-1119(97)00046-2. PMID 9210593.
^ "Entrez Gene: PDE2A phosphodiesterase 2A, cGMP-stimulated". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5138.

Witzenrath M, Gutbier B, Schmeck B et al. (2005). "Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia". Critical Care Medicine 105 (9): 584–590. doi:10.1097/CCM.0b013e3181959814. PMID 19114892.
Seybold J, Thomas D, Witzenrath M et al. (2009). "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability". Blood 37 (2): 3569–3576. doi:10.1182/blood-2004-07-2729. PMID 15650061.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Martinez SE, Wu AY, Glavas NA et al. (2002). "The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13260–13265. doi:10.1073/pnas.192374899. PMC 130621. PMID 12271124. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=130621.
Manns JM, Brenna KJ, Colman RW, Sheth SB (2002). "Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases". Thromb. Haemost. 87 (5): 873–9. PMID 12038792.
Zauli G, Milani D, Mirandola P et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–491. doi:10.1096/fj.00-0354com. PMID 11156964.
Sadhu K, Hensley K, Florio VA, Wolda SL (1999). "Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells". J. Histochem. Cytochem. 47 (7): 895–906. doi:10.1177/002215549904700707. PMID 10375378.

PDB gallery

1mc0: Regulatory Segment of Mouse 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains

1z1l: The Crystal Structure of the Phosphodiesterase 2A Catalytic Domain

PDE2A

References

Further reading