| Protocadherin alpha subfamily C, 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | PCDHAC2; MGC71598; PCDH-ALPHA-C2 | ||||||||||||
| External IDs | OMIM: 606321 MGI: 1891443 HomoloGene: 49562 GeneCards: PCDHAC2 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 56134 | 353237 | |||||||||||
| Ensembl | ENSG00000243232 | ENSMUSG00000007440 | |||||||||||
| UniProt | Q9Y5I4 | n/a | |||||||||||
| RefSeq (mRNA) | NM_018899.5 | NM_001003672.1 | |||||||||||
| RefSeq (protein) | NP_061722.1 | NP_001003672.1 | |||||||||||
| Location (UCSC) | Chr 5: 140.35 – 140.39 Mb |
Chr 18: 37.09 – 37.35 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Protocadherin alpha-C2 is a protein that in humans is encoded by the PCDHAC2 gene.[1][2]
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[2]