| Protocadherin alpha 3 | |||||||||||||
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PDB rendering based on 1wuz. |
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| Identifiers | |||||||||||||
| Symbols | PCDHA3; MGC141669; PCDH-ALPHA3 | ||||||||||||
| External IDs | OMIM: 606309 MGI: 2447313 HomoloGene: 75096 GeneCards: PCDHA3 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 56145 | 192163 | |||||||||||
| Ensembl | ENSG00000255408 | ENSMUSG00000091969 | |||||||||||
| UniProt | Q9Y5H8 | n/a | |||||||||||
| RefSeq (mRNA) | NM_018906.2 | NM_138662.1 | |||||||||||
| RefSeq (protein) | NP_061729.1 | NP_619603.1 | |||||||||||
| Location (UCSC) | Chr 5: 140.18 – 140.39 Mb |
Chr 18: 37.11 – 37.11 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Protocadherin alpha-3 is a protein that in humans is encoded by the PCDHA3 gene.[1][2]
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[2]
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