PARP4

Poly (ADP-ribose) polymerase family, member 4
Identifiers
Symbols PARP4; ADPRTL1; PARP-4; PARPL; PH5P; VAULT3; VPARP; VWA5C; p193
External IDs OMIM607519 MGI2685589 HomoloGene124423 GeneCards: PARP4 Gene
EC number 2.4.2.30
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 143 328417
Ensembl ENSG00000102699 ENSMUSG00000054509
UniProt Q9UKK3 n/a
RefSeq (mRNA) NM_006437 NM_001145978.2
RefSeq (protein) NP_006428 NP_001139450.2
Location (UCSC) Chr 13:
25 – 25.09 Mb
Chr 14:
57.19 – 57.28 Mb
PubMed search [1] [2]

Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene.[1][2]

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.[2]

Interactions

PARP4 has been shown to interact with Major vault protein.[3][4]

References

  1. ^ Still IH, Vince P, Cowell JK (Mar 2000). "Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein". Genomics 62 (3): 533–6. doi:10.1006/geno.1999.6024. PMID 10644454. 
  2. ^ a b "Entrez Gene: PARP4 poly (ADP-ribose) polymerase family, member 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=143. 
  3. ^ van Zon, Arend; Mossink Marieke H, Schoester Martijn, Scheffer George L, Scheper Rik J, Sonneveld Pieter, Wiemer Erik A C (Mar. 2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochem. Biophys. Res. Commun. (United States) 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. ISSN 0006-291X. PMID 11855821. 
  4. ^ Kickhoefer, V A; Siva A C, Kedersha N L, Inman E M, Ruland C, Streuli M, Rome L H (Sep. 1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". J. Cell Biol. (UNITED STATES) 146 (5): 917–28. doi:10.1083/jcb.146.5.917. ISSN 0021-9525. PMC 2169495. PMID 10477748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2169495. 

Further reading