PARD6B

Par-6 partitioning defective 6 homolog beta (C. elegans)

PDB rendering based on 1nf3.

Available structures
PDB	1nf3

Identifiers

Symbols

PARD6B; PAR6B

External IDs

OMIM: 608975 MGI: 2135605 HomoloGene: 23302 GeneCards: PARD6B Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• nucleus • cytoplasm • cytosol • plasma membrane • plasma membrane • tight junction • cell cortex • cell junction • apical part of cell
Biological process	• protein complex assembly • cell-cell junction assembly • cell cycle • establishment or maintenance of cell polarity • axonogenesis • regulation of cell migration • cell junction assembly • cell-cell junction organization • cell division • tight junction assembly
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 20:
49.35 – 49.37 Mb

Chr 2:
167.91 – 167.93 Mb

PubMed search

[1]

[2]

Partitioning defective 6 homolog beta is a protein that in humans is encoded by the PARD6B gene.^[1]^[2]

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.^[2]

Interactions

PARD6B has been shown to interact with CDC42,^[3]^[4]^[1] RHOQ,^[3]^[4] RAC1^[1] and Protein kinase Mζ.^[1]

References

^ ^a ^b ^c ^d Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (Mar 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256.
^ ^a ^b "Entrez Gene: PARD6B par-6 partitioning defective 6 homolog beta (C. elegans)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84612.
^ ^a ^b Neudauer, C L; Joberty G, Macara I G (Jan. 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. (United States) 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. ISSN 0006-291X. PMID 11162552.
^ ^a ^b Joberty, G; Petersen C, Gao L, Macara I G (Aug. 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. (ENGLAND) 2 (8): 531–9. doi:10.1038/35019573. ISSN 1465-7392. PMID 10934474.

Joberty G, Petersen C, Gao L, Macara IG (2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474.
Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Gao L, Macara IG, Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties". Gene 294 (1–2): 99–107. doi:10.1016/S0378-1119(02)00681-9. PMID 12234671.
Kohjima M, Noda Y, Takeya R et al. (2003). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Hurd TW, Gao L, Roh MH et al. (2003). "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly". Nat. Cell Biol. 5 (2): 137–42. doi:10.1038/ncb923. PMID 12545177.
Yamanaka T, Horikoshi Y, Sugiyama Y et al. (2004). "Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity". Curr. Biol. 13 (9): 734–43. doi:10.1016/S0960-9822(03)00244-6. PMID 12725730.
Brajenovic M, Joberty G, Küster B et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Labhart P, Karmakar S, Salicru EM et al. (2005). "Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1339–44. doi:10.1073/pnas.0409578102. PMC 547886. PMID 15677324. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=547886.

PDB gallery

1nf3: Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6

PARD6B

Interactions

References

Further reading