PAFAH1B2

Platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)

PDB rendering based on 1fxw.

Available structures
PDB	1fxw, 1vyh

Identifiers

Symbols

PAFAH1B2;

External IDs

OMIM: 602508 MGI: 108415 HomoloGene: 1932 GeneCards: PAFAH1B2 Gene

EC number

3.1.1.47

Gene Ontology
Molecular function	• 1-alkyl-2-acetylglycerophosphocholine esterase activity • hydrolase activity, acting on ester bonds
Cellular component	• cytoplasm
Biological process	• lipid metabolic process • lipid catabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
117.01 – 117.05 Mb

Chr 9:
45.77 – 45.79 Mb

PubMed search

[1]

[2]

Platelet-activating factor acetylhydrolase IB subunit beta is an enzyme that in humans is encoded by the PAFAH1B2 gene.^[1]^[2]^[3]

1 Interactions
2 See also
3 References
4 Further reading

Interactions

PAFAH1B2 has been shown to interact with PAFAH1B1.^[4]

References

^ Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K (Jun 1997). "Differential tissue distribution of the beta- and gamma-subunits of human cytosolic platelet-activating factor acetylhydrolase (isoform I)". Biochem Biophys Res Commun 233 (1): 10–3. doi:10.1006/bbrc.1997.6383. PMID 9144386.
^ Moro F, Arrigo G, Fogli A, Bernard L, Carrozzo R (Sep 1998). "The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively". Genomics 51 (1): 157–9. doi:10.1006/geno.1998.5322. PMID 9693049.
^ "Entrez Gene: PAFAH1B2 platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5049.
^ Sweeney, K J; Clark G D, Prokscha A, Dobyns W B, Eichele G (Apr. 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mech. Dev. (IRELAND) 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. ISSN 0925-4773. PMID 10727864.

Albrecht U, Abu-Issa R, Rätz B, et al. (1997). "Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor.". Dev. Biol. 180 (2): 579–93. doi:10.1006/dbio.1996.0330. PMID 8954729.
Sweeney KJ, Clark GD, Prokscha A, et al. (2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development.". Mech. Dev. 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864.
Sheffield PJ, McMullen TW, Li J, et al. (2001). "Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib.". Protein Eng. 14 (7): 513–9. doi:10.1093/protein/14.7.513. PMID 11522926.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Hasstedt SJ, Scott BT, Rosendaal FR, et al. (2007). "Exclusion of the alpha2 subunit of platelet-activating factor acetylhydrolase 1b (PAFAH1B2) as a prothrombotic gene in a protein C-deficient kindred and population-based case-control sample". Thromb. Haemost. 98 (3): 587–92. PMID 17849047.

PDB gallery

1fxw: CRYSTAL STRUCTURE OF THE RECOMBINANT ALPHA1/ALPHA2 CATALYTIC HETERODIMER OF BOVINE BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB.

1vyh: PAF-AH HOLOENZYME: LIS1/ALFA2

PAFAH1B2

Contents

Interactions

See also

References

Further reading