PACSIN1

Protein kinase C and casein kinase substrate in neurons 1

Rendering based on PDB 3ABH.

Available structures
PDB	3ABH, 3ACO, 3HAH, 3HAI, 3HAJ

Identifiers

Symbols

PACSIN1; KIAA1379; SDPI

External IDs

OMIM: 606512 MGI: 1345181 HomoloGene: 22674 GeneCards: PACSIN1 Gene

Gene Ontology
Molecular function	• protein kinase activity • protein binding • cytoskeletal protein binding
Cellular component	• cytoplasm • cytoplasm • COPI-coated vesicle
Biological process	• protein phosphorylation • endocytosis • cytoskeleton organization • negative regulation of endocytosis
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
34.43 – 34.5 Mb

Chr 17:
27.79 – 27.85 Mb

PubMed search

[1]

[2]

Protein kinase C and casein kinase substrate in neurons protein 1 is an enzyme that in humans is encoded by the PACSIN1 gene.^[1]^[2]

Interactions

PACSIN1 has been shown to interact with DNM1,^[3]^[4] PACSIN3,^[4] Huntingtin^[5] and PACSIN2.^[6]^[4]

References

^ Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M (Feb 2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family". Gene 262 (1-2): 199–205. doi:10.1016/S0378-1119(00)00531-X. PMID 11179684.
^ "Entrez Gene: PACSIN1 protein kinase C and casein kinase substrate in neurons 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29993.
^ Kamioka, Yuji; Fukuhara Shigetomo, Sawa Hirofumi, Nagashima Kazuo, Masuda Michitaka, Matsuda Michiyuki, Mochizuki Naoki (Sep. 2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". J. Biol. Chem. (United States) 279 (38): 40091–9. doi:10.1074/jbc.M404899200. ISSN 0021-9258. PMID 15252009.
^ ^a ^b ^c Modregger, J; Ritter B, Witter B, Paulsson M, Plomann M (Dec. 2000). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". J. Cell. Sci. (ENGLAND) 113 Pt 24: 4511–21. ISSN 0021-9533. PMID 11082044.
^ Modregger, Jan; DiProspero Nicholas A, Charles Vinod, Tagle Danilo A, Plomann Markus (Oct. 2002). "PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains". Hum. Mol. Genet. (England) 11 (21): 2547–58. doi:10.1093/hmg/11.21.2547. ISSN 0964-6906. PMID 12354780.
^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Qualmann B, Roos J, DiGregorio PJ, Kelly RB (1999). "Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein.". Mol. Biol. Cell 10 (2): 501–13. PMC 25183. PMID 9950691. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25183.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
Modregger J, Ritter B, Witter B, et al. (2001). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.". J. Cell. Sci. 113 Pt 24: 4511–21. PMID 11082044.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Zucconi A, Dente L, Santonico E, et al. (2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1.". J. Mol. Biol. 307 (5): 1329–39. doi:10.1006/jmbi.2001.4572. PMID 11292345.
Wasiak S, Quinn CC, Ritter B, et al. (2001). "The Ras/Rac guanine nucleotide exchange factor mammalian Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton.". J. Biol. Chem. 276 (28): 26622–8. doi:10.1074/jbc.M100591200. PMID 11352907.
Modregger J, DiProspero NA, Charles V, et al. (2003). "PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains.". Hum. Mol. Genet. 11 (21): 2547–58. doi:10.1093/hmg/11.21.2547. PMID 12354780.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Kamioka Y, Fukuhara S, Sawa H, et al. (2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis.". J. Biol. Chem. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501.
Cuajungco MP, Grimm C, Oshima K, et al. (2006). "PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4.". J. Biol. Chem. 281 (27): 18753–62. doi:10.1074/jbc.M602452200. PMID 16627472.

PACSIN1

Interactions

References

Further reading