PACS1
Phosphofurin acidic cluster sorting protein 1 also known as PACS-1 is a protein that in humans is encoded by the PACS1 gene.[1][2][3]
Function
The PACS-1 protein has a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.[3]
Interactions
PACS1 has been shown to interact with Furin.[4]
References
- ^ Stove V, Naessens E, Stove C, Swigut T, Plum J, Verhasselt B (Oct 2003). "Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development". Blood 102 (8): 2925–32. doi:10.1182/blood-2003-03-0833. PMID 12855553.
- ^ Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA (Dec 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Rep 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. PMC 1326413. PMID 14608369. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1326413.
- ^ a b "Entrez Gene: PACS1 phosphofurin acidic cluster sorting protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55690.
- ^ Wan, L; Molloy S S, Thomas L, Liu G, Xiang Y, Rybak S L, Thomas G (Jul. 1998). "PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization". Cell (UNITED STATES) 94 (2): 205–16. doi:10.1016/S0092-8674(00)81420-8. ISSN 0092-8674. PMID 9695949.
Further reading
- Geyer M, Fackler OT, Peterlin BM (2001). "Structure–function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC 1083955. PMID 11463741. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083955.
- Leavitt SA, SchOn A, Klein JC et al. (2004). "Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm". Curr. Protein Pept. Sci. 5 (1): 1–8. doi:10.2174/1389203043486955. PMID 14965316.
- Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection". Curr. HIV Res. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
- Wan L, Molloy SS, Thomas L et al. (1998). "PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization". Cell 94 (2): 205–16. doi:10.1016/S0092-8674(00)81420-8. PMID 9695949.
- Hirosawa M, Nagase T, Ishikawa K et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
- Piguet V, Wan L, Borel C et al. (2000). "HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes". Nat. Cell Biol. 2 (3): 163–7. doi:10.1038/35004038. PMC 1475706. PMID 10707087. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1475706.
- Crump CM, Xiang Y, Thomas L et al. (2001). "PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic". EMBO J. 20 (9): 2191–201. doi:10.1093/emboj/20.9.2191. PMC 125242. PMID 11331585. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125242.
- Williams M, Roeth JF, Kasper MR et al. (2002). "Direct Binding of Human Immunodeficiency Virus Type 1 Nef to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail Disrupts MHC-I Trafficking". J. Virol. 76 (23): 12173–84. doi:10.1128/JVI.76.23.12173-12184.2002. PMC 136906. PMID 12414957. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=136906.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Blagoveshchenskaya AD, Thomas L, Feliciangeli SF et al. (2003). "HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway". Cell 111 (6): 853–66. doi:10.1016/S0092-8674(02)01162-5. PMID 12526811.
- Scott GK, Gu F, Crump CM et al. (2004). "The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic". EMBO J. 22 (23): 6234–44. doi:10.1093/emboj/cdg596. PMC 291837. PMID 14633983. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=291837.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Köttgen M, Benzing T, Simmen T et al. (2005). "Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation". EMBO J. 24 (4): 705–16. doi:10.1038/sj.emboj.7600566. PMC 549624. PMID 15692563. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=549624.