RELA

V-rel reticuloendotheliosis viral oncogene homolog A (avian)

PDB rendering based on 1bft.
Identifiers
Symbols RELA; MGC131774; NFKB3; p65
External IDs OMIM164014 MGI103290 HomoloGene32064 GeneCards: RELA Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5970 19697
Ensembl ENSG00000173039 ENSMUSG00000024927
UniProt Q04206 Q3U3Q8
RefSeq (mRNA) NM_001145138.1 NM_009045.4
RefSeq (protein) NP_001138610.1 NP_033071.1
Location (UCSC) Chr 11:
65.42 – 65.43 Mb
Chr 19:
5.64 – 5.65 Mb
PubMed search [1] [2]

Transcription factor p65 is a protein that in humans is encoded by the RELA gene.[1]

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NF-κB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NF-κB. The NF-κB complex is inhibited by IκB (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NF-κB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-κB complex. Activated NF-κB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM][2]

Contents

Interactions

RELA has been shown to interact with NFKBIB,[3][4] ETHE1,[5] NFKBIE,[6] RFC1,[7] TRIB3,[8] CREB binding protein,[9][10][11][12][13] Neutrophil cytosolic factor 1,[14] Glucocorticoid receptor,[15][16][17] MTPN,[18] BRCA1,[19] C-Fos,[20] POU2F1,[21] BTRC,[22] TATA-binding protein,[23][24] IκBα,[22][25][26][27][28][29][30] NFKB2,[31][32] NFKB1,[31][33] Nuclear receptor co-repressor 2,[34][35] Aryl hydrocarbon receptor,[36][37] CEBPB,[38][39] HDAC3,[25] DHX9,[40] PARP1,[41] ASCC3,[42] HDAC1,[10][26][43] CSNK2A2,[44] Histone deacetylase 2,[26][45] Casein kinase 2, alpha 1,[44] Protein kinase Mζ,[46] STAT3,[47] RNF25,[48] Sp1 transcription factor,[49][50] CDK9,[51] TAF4B,[52] MEN1,[53] PPP1R13L,[54][55] APBA2,[56] REL,[28][31][57] ING4,[58] EP300,[13][26] FUS,[59] PIAS3[9] and C-jun.[20]

References

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Further reading

  • Baldwin AS (1996). "The NF-kappa B and I kappa B proteins: new discoveries and insights.". Annu. Rev. Immunol. 14: 649–83. doi:10.1146/annurev.immunol.14.1.649. PMID 8717528. 
  • Bottex-Gauthier C, Pollet S, Favier A, Vidal DR (2002). "[The Rel/NF-kappa-B transcription factors: complex role in cell regulation]". Pathol. Biol. 50 (3): 204–11. PMID 11980335. 
  • Garg A, Aggarwal BB (2002). "Nuclear transcription factor-kappaB as a target for cancer drug development.". Leukemia 16 (6): 1053–68. doi:10.1038/sj.leu.2402482. PMID 12040437. 
  • Clarke R, Liu MC, Bouker KB, et al. (2003). "Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling.". Oncogene 22 (47): 7316–39. doi:10.1038/sj.onc.1206937. PMID 14576841. 

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