P2RX6

Purinergic receptor P2X, ligand-gated ion channel, 6
Identifiers
Symbols P2RX6; MGC129625; P2RXL1; P2X6; P2XM
External IDs OMIM: 608077 MGI: 1337113 HomoloGene: 3975 IUPHAR: GeneCards: P2RX6 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 9127 18440
Ensembl ENSG00000099957 ENSMUSG00000022758
UniProt O15547 Q3UUD0
RefSeq (mRNA) NM_001159554.1 NM_011028
RefSeq (protein) NP_001153026.1 NP_035158
Location (UCSC) Chr 22:
21.37 – 21.38 Mb		 Chr 16:
17.56 – 17.58 Mb
PubMed search [1] [2]

P2X purinoceptor 6 is a protein that in humans is encoded by the P2RX6 gene.[1][2][3][4]

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.[4]

Contents

See also

References

  1. ^ Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T (Sep 1997). "Cloning of P2XM, a novel human P2X receptor gene regulated by p53". Cancer Res 57 (15): 3281–7. PMID 9242461. 
  2. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  3. ^ Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (Sep 1996). "Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels". J Neurosci 16 (8): 2495–507. PMID 8786426. 
  4. ^ a b "Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9127. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cys-loop receptors
5-HT3 (A, B, C, D, E)
GABAA (α1, α2, α3, α4, α5, α6, β1, β2, β3, γ1, γ2, γ3, δ, ε, π, θ) · GABAA-ρ (ρ1, ρ2, ρ3)
α1 · α2 · α3 · α4 · β
monomers: α1 · α2 · α3 · α4 · α5 · α6 · α7 · α9 · α10 · β1 · β2 · β3 · β4 · δ · ε
pentamers: (α3)2(β4)3 · (α4)2(β2)3 · (α7)5 · (α1)2(β4)3 - Ganglion type · (α1)2β1δε - Muscle type
Zinc
Ionotropic glutamates
Ligand-gated only
AMPA (1, 2, 3, 4) · Kainate (1, 2, 3, 4, 5)
Voltage- and ligand-gated
NMDA (1, 2A, 2B, 2C, 2D, 3A, 3B, L1A, L1B)
‘Orphan’
GluD (δ1, δ2)
ATP-gated channels
P2X (1, 2, 3, 4, 5, 6, 7)
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)