P antigen system

P antigen system is a human blood group system based upon genes on chromosome 22. The P antigens are carbohydrate antigens that include P₁, P, and P^k. The P antigen is a receptor for the human pathogen Parvovirus B19^[1] and is the target of auto-anti-P IgG antibodies in paroxysmal cold hemoglobinuria.^[2]

References

1. ^ Resistance to Parvovirus B19 Infection Due to Lack of Virus Receptor (Erythrocyte P Antigen) by Kevin E. Brown, Jonathan R. Hibbs, Giorgio Gallinella, Stacie M. Anderson, Elton D. Lehman, Peggy McCarthy, and Neal S. Young. NEJM Volume 330:1192-1196 April 28, 1994 Number 17
2. ^ STUDIES ON THE SEROLOGY OF PAROXYSMAL COLD HAEMOGLOBINURIA (P.G.H.), WITH SPECIAL REFERENCE TO ITS RELATIONSHIP WITH THE P BLOOD GROUP SYSTEM. WORLLEDGE SM, ROUSSO C. Vox Sang. 1965 May-Jun;10:293-8.

External links

• P at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH