Oxyphenisatine | |
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3,3-Bis(4-hydroxyphenyl)-1,3-dihydro-2H-indol-2-one |
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Identifiers | |
CAS number | 125-13-3 |
PubChem | 31315 |
ChemSpider | 29053 |
UNII | 3BT0VQG2GQ |
EC number | 204-728-1 |
DrugBank | DB04823 |
KEGG | D08326 |
ChEMBL | CHEMBL245807 |
ATC code | A06 |
Jmol-3D images | Image 1 Image 2 |
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Properties | |
Molecular formula | C20NH15O3 |
Exact mass | 317.105193351 g mol-1 |
log P | 1.398 |
Acidity (pKa) | 9.423 |
Basicity (pKb) | 4.574 |
Pharmacology | |
Routes of administration |
Oral, rectal |
Legal status | |
(verify) (what is: / ?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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Infobox references |
Oxyphenisatine (or oxyphenisatin) is a laxative.[3] It is closely related to bisacodyl, sodium picosulfate, and phenolphthalein. Long term use is associated with liver damage,[4] and as a result, it was withdrawn in most countries in the early 1970s. The acetate derivative oxyphenisatine acetate was also once used as a laxative.
Natural chemical compounds similar to oxyphenisatine may be present in prunes,[5] but a recent review of the relevant scientific literature suggests that the laxative effect of prunes is due to other constituents including phenolic compounds (mainly neochlorogenic acids and chlorogenic acids) and sorbitol.[6]
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