Ombrabulin

Ombrabulin
IUPAC name

(2S)-2-Amino-3-hydroxy-N-[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]propanamide
Other names

AVE-8062; AVE-8062A; AC7700; CS-39-L-Ser.HCl
Identifiers
CAS number 181816-48-8 Y, 253426-24-3 (HCl) Y
PubChem 6918405, 6918404 (HCl)
Jmol-3D images Image 1
Properties
Molecular formula C21H26N2O6
Molar mass 402.44 g mol−1
 Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Ombrabulin is an experimental drug candidate discovered by Ajinomoto and under development by Sanofi-Aventis.[1] It is currently in Phase III clinical trials for the treatment of advanced-stage soft-tissue sarcoma.[1]

Ombrabulin was granted orphan drug status by the European Medicines Agency in April 2011.[2]

Ombrabulin is a combretastatin A-4 derivative that exerts its antitumor effect by disrupting the formation of blood vessels needed for tumor growth.[3][4]

References

  1. ^ a b "Ombrabulin (AVE8062)". Sanofi-Aventis Oncology. http://www.sanofi-aventisoncology.com/wps/portal/oncology/pipeline/ombrabulin. 
  2. ^ "Orphan Designation EU/3/11/853". European Medicines Agency. 15 April 2011. http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/orphans/2011/04/human_orphan_000912.jsp&mid=WC0b01ac058001d12b&murl=menus/medicines/medicines.jsp&jsenabled=true. 
  3. ^ Hori, K; Saito, S; Nihei, Y; Suzuki, M; Sato, Y (1999). "Antitumor effects due to irreversible stoppage of tumor tissue blood flow: evaluation of a novel combretastatin A-4 derivative, AC7700". Japanese journal of cancer research : Gann 90 (9): 1026–38. PMID 10551334. 
  4. ^ Hori, K; Saito, S; Kubota, K (2002). "A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs". British journal of cancer 86 (10): 1604–14. doi:10.1038/sj.bjc.6600296. PMC 2746587. PMID 12085211. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2746587.