OXSR1

Oxidative-stress responsive 1

Rendering based on PDB 2V3S.

Available structures
PDB	2V3S, 2VWI, 3DAK

Identifiers

Symbols

OXSR1; KIAA1101; OSR1

External IDs

OMIM: 604046 MGI: 1917378 HomoloGene: 31288 GeneCards: OXSR1 Gene

EC number

2.7.11.1

Gene Ontology
Molecular function	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • protein binding • ATP binding • identical protein binding
Biological process	• protein phosphorylation • response to oxidative stress • intracellular protein kinase cascade
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
38.21 – 38.3 Mb

Chr 9:
119.15 – 119.23 Mb

PubMed search

[1]

[2]

Serine/threonine-protein kinase OSR1 is an enzyme that in humans is encoded by the OXSR1 gene.^[1]^[2]

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.^[2]

References

^ Tamari M, Daigo Y, Nakamura Y (Apr 1999). "Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3". J Hum Genet 44 (2): 116–20. doi:10.1007/s100380050121. PMID 10083736.
^ ^a ^b "Entrez Gene: OXSR1 oxidative-stress responsive 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9943.

Daigo Y, Isomura M, Nishiwaki T, et al. (1999). "Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3.". DNA Res. 6 (1): 37–44. doi:10.1093/dnares/6.1.37. PMID 10231028.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
Piechotta K, Lu J, Delpire E (2003). "Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).". J. Biol. Chem. 277 (52): 50812–9. doi:10.1074/jbc.M208108200. PMID 12386165.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Chen W, Yazicioglu M, Cobb MH (2004). "Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.". J. Biol. Chem. 279 (12): 11129–36. doi:10.1074/jbc.M313562200. PMID 14707132.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Moriguchi T, Urushiyama S, Hisamoto N, et al. (2006). "WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.". J. Biol. Chem. 280 (52): 42685–93. doi:10.1074/jbc.M510042200. PMID 16263722.
Cusick JK, Xu LG, Bin LH, et al. (2006). "Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1.". Biochem. Biophys. Res. Commun. 340 (2): 535–43. doi:10.1016/j.bbrc.2005.12.033. PMID 16389068.
Vitari AC, Thastrup J, Rafiqi FH, et al. (2006). "Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.". Biochem. J. 397 (1): 223–31. doi:10.1042/BJ20060220. PMC 1479760. PMID 16669787. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1479760.
Anselmo AN, Earnest S, Chen W, et al. (2006). "WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.". Proc. Natl. Acad. Sci. U.S.A. 103 (29): 10883–8. doi:10.1073/pnas.0604607103. PMC 1544143. PMID 16832045. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1544143.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
Villa F, Goebel J, Rafiqi FH, et al. (2007). "Structural insights into the recognition of substrates and activators by the OSR1 kinase.". EMBO Rep. 8 (9): 839–45. doi:10.1038/sj.embor.7401048. PMC 1973955. PMID 17721439. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1973955.

OXSR1

References

Further reading