OPCML

Opioid binding protein/cell adhesion molecule-like

Identifiers

OPCML; IGLON1; OBCAM; OPCM

External IDs

OMIM: 600632 MGI: 97397 HomoloGene: 55663 GeneCards: OPCML Gene

Gene Ontology
Molecular function	• opioid receptor activity
Cellular component	• plasma membrane • integral to plasma membrane • anchored to membrane
Biological process	• cell adhesion • neuron recognition • opioid receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
132.28 – 133.4 Mb

Chr 9:
27.6 – 28.73 Mb

PubMed search

[1]

[2]

Opioid-binding protein/cell adhesion molecule is a protein that in humans is encoded by the OPCML gene.^[1]^[2]

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene.^[2]

References

^ Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y, et al. (Dec 1993). "A sequence-tagged site map of human chromosome 11". Genomics 17 (3): 699–725. doi:10.1006/geno.1993.1392. PMID 8244387.
^ ^a ^b "Entrez Gene: OPCML opioid binding protein/cell adhesion molecule-like". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4978.

Lane CM, Elde R, Loh HH, Lee NM (1993). "Regulation of an opioid-binding protein in NG108-15 cells parallels regulation of delta-opioid receptors". Proc. Natl. Acad. Sci. U.S.A. 89 (23): 11234–8. doi:10.1073/pnas.89.23.11234. PMC 50524. PMID 1333602. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=50524.
Shark KB, Lee NM (1995). "Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM)". Gene 155 (2): 213–7. doi:10.1016/0378-1119(94)00830-L. PMID 7721093.
Struyk AF, Canoll PD, Wolfgang MJ, et al. (1995). "Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules". J. Neurosci. 15 (3 Pt 2): 2141–56. PMID 7891157.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Sellar GC, Watt KP, Rabiasz GJ, et al. (2003). "OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer". Nat. Genet. 34 (3): 337–43. doi:10.1038/ng1183. PMID 12819783.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Schmitt-Ulms G, Hansen K, Liu J, et al. (2005). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nat. Biotechnol. 22 (6): 724–31. doi:10.1038/nbt969. PMID 15146195.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Mei FC, Young TW, Liu J, Cheng X (2006). "RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells". FASEB J. 20 (3): 497–9. doi:10.1096/fj.05-4586fje. PMID 16384911.
Wang L, Zhu JS, Song MQ, et al. (2007). "Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray". World J. Gastroenterol. 12 (43): 6949–54. PMID 17109515.
Czekierdowski A, Czekierdowska S, Szymanski M, et al. (2007). "Opioid-binding protein/cell adhesion molecule-like (OPCML) gene and promoter methylation status in women with ovarian cancer". Neuro Endocrinol. Lett. 27 (5): 609–13. PMID 17159813.
Reed JE, Dunn JR, du Plessis DG, et al. (2007). "Expression of cellular adhesion molecule 'OPCML' is down-regulated in gliomas and other brain tumours". Neuropathol. Appl. Neurobiol. 33 (1): 77–85. doi:10.1111/j.1365-2990.2006.00786.x. PMID 17239010.

OPCML

References

Further reading