OAS1

2',5'-oligoadenylate synthetase 1, 40/46kDa

Identifiers

OAS1; IFI-4; OIAS; OIASI

External IDs

OMIM: 164350 HomoloGene: 1903 GeneCards: OAS1 Gene

2.7.7.-

Gene Ontology
Molecular function	• nucleotide binding • RNA binding • ATP binding • transferase activity • nucleotidyltransferase activity
Cellular component	• nucleus • cytoplasm • mitochondrion • endoplasmic reticulum • microsome
Biological process	• nucleobase, nucleoside, nucleotide and nucleic acid metabolic process • immune response • cytokine-mediated signaling pathway • interferon-gamma-mediated signaling pathway • type I interferon-mediated signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
113.34 – 113.37 Mb

Chr 5:
121.33 – 121.34 Mb

PubMed search

[1]

[2]

2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene.^[1]^[2]

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.^[3]

References

^ Renault B, Hovnanian A, Bryce S, Chang JJ, Lau S, Sakuntabhai A, Monk S, Carter S, Ross CJ, Pang J, Twells R, Chamberlain S, Monaco AP, Strachan T, Kucherlapati R (Feb 1998). "A sequence-ready physical map of a region of 12q24.1". Genomics 45 (2): 271–8. doi:10.1006/geno.1997.4888. PMID 9344649.
^ Nechiporuk T, Nechiporuk A, Sahba S, Figueroa K, Shibata H, Chen XN, Korenberg JR, de Jong P, Pulst SM (Nov 1997). "A high-resolution PAC and BAC map of the SCA2 region". Genomics 44 (3): 321–9. doi:10.1006/geno.1997.4886. PMID 9325053.
^ "Entrez Gene: OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4938.

Justesen J, Hartmann R, Kjeldgaard NO (2000). "Gene structure and function of the 2'-5'-oligoadenylate synthetase family.". Cell. Mol. Life Sci. 57 (11): 1593–612. doi:10.1007/PL00000644. PMID 11092454.
Ghosh SK, Kusari J, Bandyopadhyay SK, et al. (1991). "Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases. Structure-function relationships.". J. Biol. Chem. 266 (23): 15293–9. PMID 1651324.
Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes.". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818.
Saunders ME, Gewert DR, Tugwell ME, et al. (1985). "Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure.". EMBO J. 4 (7): 1761–8. PMC 554415. PMID 2411547. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=554415.
Benech P, Mory Y, Revel M, Chebath J (1986). "Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences.". EMBO J. 4 (9): 2249–56. PMC 554493. PMID 2416561. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=554493.
Williams BR, Saunders ME, Willard HF (1986). "Interferon-regulated human 2-5A synthetase gene maps to chromosome 12.". Somat. Cell Mol. Genet. 12 (4): 403–8. doi:10.1007/BF01570735. PMID 2426799.
Hovanessian AG, Laurent AG, Chebath J, et al. (1987). "Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies.". EMBO J. 6 (5): 1273–80. PMC 553929. PMID 2440675. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=553929.
Rutherford MN, Hannigan GE, Williams BR (1988). "Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene.". EMBO J. 7 (3): 751–9. PMC 454386. PMID 2456211. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=454386.
Benech P, Vigneron M, Peretz D, et al. (1988). "Interferon-responsive regulatory elements in the promoter of the human 2',5'-oligo(A) synthetase gene.". Mol. Cell. Biol. 7 (12): 4498–504. PMC 368134. PMID 2830497. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=368134.
Wathelet MG, Clauss IM, Nols CB, et al. (1988). "New inducers revealed by the promoter sequence analysis of two interferon-activated human genes.". Eur. J. Biochem. 169 (2): 313–21. doi:10.1111/j.1432-1033.1987.tb13614.x. PMID 3121313.
Wathelet MG, Szpirer J, Nols CB, et al. (1988). "Cloning and chromosomal location of human genes inducible by type I interferon.". Somat. Cell Mol. Genet. 14 (5): 415–26. doi:10.1007/BF01534709. PMID 3175763.
Wathelet M, Moutschen S, Cravador A, et al. (1986). "Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon.". FEBS Lett. 196 (1): 113–20. doi:10.1016/0014-5793(86)80224-1. PMID 3753689.
Shiojiri S, Fukunaga R, Ichii Y, Sokawa Y (1986). "Structure and expression of a cloned cDNA for human (2'-5')oligoadenylate synthetase.". J. Biochem. 99 (5): 1455–64. PMID 3754863.
Merlin G, Chebath J, Benech P, et al. (1983). "Molecular cloning and sequence of partial cDNA for interferon-induced (2'-5')oligo(A) synthetase mRNA from human cells.". Proc. Natl. Acad. Sci. U.S.A. 80 (16): 4904–8. doi:10.1073/pnas.80.16.4904. PMC 384155. PMID 6348777. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=384155.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Ghosh A, Sarkar SN, Guo W, et al. (1998). "Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein.". J. Biol. Chem. 272 (52): 33220–6. doi:10.1074/jbc.272.52.33220. PMID 9407111.
Hovnanian A, Rebouillat D, Mattei MG, et al. (1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms.". Genomics 52 (3): 267–77. doi:10.1006/geno.1998.5443. PMID 9790745.
Sarkar SN, Ghosh A, Wang HW, et al. (1999). "The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases.". J. Biol. Chem. 274 (36): 25535–42. doi:10.1074/jbc.274.36.25535. PMID 10464285.

OAS1

References

Further reading