Nucleoporin

Structure of nucleoporin Nup107/Nup133 interaction complex, delta finger mutant.

Identifiers

Symbol

Nucleoporin

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

The nucleoporins are a family of proteins which are the constituent building blocks of the nuclear pore complex.^[1] The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the cell nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. Nuclear pores in turn allow the transport of water-soluble molecules across the nuclear envelope.

The proteins involved are named for their molecular weight (in kilo Daltons), and include the following:

NUP35, NUP37, NUP43, NUP50
NUP54, NUP62, NUP85, NUP88, NUP93, NUP98
NUP107, NUP133, NUP153, NUP155, NUP160, NUP188
NUP205, NUP210, NUP214

References

^ Doye V, Hurt E (June 1997). "From nucleoporins to nuclear pore complexes". Curr. Opin. Cell Biol. 9 (3): 401–11. doi:10.1016/S0955-0674(97)80014-2. PMID 9159086.

External links

MeSH Nucleoporin

Structures of the cell nucleus / nuclear protein

Envelope (membrane)/ nuclear lamina	Pore complex: Nucleoporin (NUP35, NUP37, NUP43, NUP50, NUP54, NUP62, NUP85, NUP88, NUP93, NUP98, NUP107, NUP133, NUP153, NUP155, NUP160, NUP188, NUP205, NUP210, NUP214) · AAAS

Nucleolus	Cajal (coiled) body (GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, SMN/SIP1, COIL) · Perinucleolar compartment (PTBP1, CUGBP1) TCOF · ATXN7

Other	Chromatin · Dot (PML body) · Paraspeckle SMC protein: Cohesin (SMC1A, SMC1B, SMC3) · Condensin (NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NCAPH2, SMC2, SMC4) · DNA repair (SMC5, SMC6) Transition nuclear protein: TNP1, TNP2 Nuclear matrix · Nucleoplasm · Nucleoskeleton · Nucleosol LITAF see also transcription factors and intracellular receptors

see also nucleus diseases B strc: edmb (perx), skel (ctrs), epit, cili, mito, nucl (chro)