Nitroxoline

Nitroxoline
Systematic (IUPAC) name
5-nitroquinolin-8-ol
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 4008-48-4 Y
ATC code J01XX07
PubChem CID 19910
DrugBank DB01422
ChemSpider 18756 Y
UNII A8M33244M6 Y
KEGG D07245 Y
ChEMBL CHEMBL1454910 N
Chemical data
Formula C9H6N2O3 
Mol. mass 190.156 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Nitroxoline is an antibiotic.[1]

It was recently discovered that nitroxoline has antiangiogenic properties, which could make it useful as an anti-cancer drug. [2]

References

  1. ^ Pelletier C, Prognon P, Bourlioux P (1995). "Roles of divalent cations and pH in mechanism of action of nitroxoline against Escherichia coli strains". Antimicrob. Agents Chemother. 39 (3): 707–13. PMC 162609. PMID 7793877. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=7793877. 
  2. ^ Joong Sup Shim, Yoshiyuki Matsui, Shridhar Bhat, Benjamin A. Nacev, Jing Xu, Hyo-eun C. Bhang, Surajit Dhara, Kee Chung Han, Curtis R. Chong, Martin G. Pomper, Alan So Jun O. Liu (2010). "Effect of Nitroxoline on Angiogenesis and Growth of Human Bladder Cancer". J Natl Cancer Inst. 102 (24): 1855–1873. doi:10.1093/jnci/djq457. PMC 3001967. PMID 21088277. http://jnci.oxfordjournals.org/content/102/24/1855.full. 
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