Netilmicin

Netilmicin
Systematic (IUPAC) name
(2R,3R,4R,5R)-​2-​{[(1S,2S,3R,4S,6R)-​4-​amino-​3-​{[(2S,3R)-​3-​amino-​6-​(aminomethyl)-​3,4-​dihydro-2H-​pyran-​2-​yl]oxy}-​6-​(ethylamino)-​2-​hydroxycyclohexyl]oxy}-​5-​methyl-​4-​(methylamino)oxane-​3,5-diol
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a605011
Pregnancy cat.  ?
Legal status  ?
Pharmacokinetic data
Bioavailability ~0%
Half-life 2.5 hours
Identifiers
CAS number 56391-56-1 Y
ATC code J01GB07 S01AA23
PubChem CID 41859
DrugBank APRD00232
ChemSpider 38195 Y
UNII 4O5J85GJJB Y
KEGG D08268 Y
ChEMBL CHEMBL1572 N
Chemical data
Formula C21H41N5O7 
Mol. mass 475.58 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.

Contents

Available dosage forms

Available dosage forms include:

Ingredients for 100 mg/mL vial

Netilmicin (as sulphate) 100 mg
Sodium metabisulfite 2.4 mg
Sodium sulfite 0.8 mg
Edetate disodium 0.1 mg
Benzyl alcohol 10 mg
Water for injection qs 1 mL

FDA approval date : February 28, 1983

Comparison with drugs of the same therapeutic category

According to the British National Formulary (BNF), netilmicin has similar activity to gentamicin, but less ototoxicity in those needing treatment for longer than 10 days.Netilmicin is active against a number of gentamicin-resistant Gram-negative bacilli but is less active against Ps. Aeuroginosa than gentamicin or tobramycin.

However according to the below-mentioned studies, the above advantages are somehow controversial:

External links