Astilbin

Astilbin
IUPAC name

(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3-dihydrochromen-4-one
Other names

Isoastilbin
Neoastilbin
Neoisoastilbin
Taxifolin 3-O-rhamnoside
Taxifolin 3-rhamnoside
(2R-trans)-3-((6-Deoxy-alpha-L-mannopyranosyl)oxy)-2-(3,4- dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one[1]
Identifiers
CAS number 54141-72-9 Y
PubChem 119258
ChemSpider 106533 Y
Jmol-3D images Image 1
Properties
Molecular formula C21H22O11
Molar mass 450.39 g/mol
Exact mass 450.116212 u
Appearance brown powder[1]
 Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Astilbin is a flavanonol, a type of flavonoid. Astilbin is the (2R-trans)-isomer; neoisoastilbin is the (2S-cis)-isomer and isoastilbin is the (2R-cis)-isomer.[2]

Astilbin can be found in St John's wort (Hypericum perforatum, Clusiaceae, subfamily Hypericoideae, formerly often considered a full family Hypericaceae), in Dimorphandra mollis[3] (Fava d'anta, Fabaceae), in the leaves of Harungana madagascariensis (Hypericaceae),[4] in the rhizome of Astilbe thunbergii,[5] in the root of Astilbe odontophylla[6](Saxifragaceae), in the rhizone of Smilax glabra[7] (Chinaroot, Smilacaceae) and in the bark of Hymenaea martiana.[8] It can be isolated from Kohki tea processed from Engelhardtia chrysolepis (huang-qui).[2]

Uses

Astilbin can act as an insecticide against Anticarsia gemmatalis and Spodoptera frugiperda.[3] It shows in vitro antibacterial activity[4] and activity on burn wound healing.[5] Astilbin is used in traditional Chinese medicine.[6]

Related compounds

3'-O-Methylastilbin shows an immunosuppressive activity against contact dermatitis.[7]

References

  1. ^ a b http://anwabio.com/asti.htm
  2. ^ a b Astilbin on PubChem
  3. ^ a b Biological activity of astilbin from Dimorphandra mollis against Anticarsia gemmatalis and Spodoptera frugiperda, Luciane G Batista Pereira, Fernando Petacci, João B Fernandes, Arlene G Corrêa, Paulo C Vieira 1, M Fátima G F da Silva, Osmar Malaspina, 2002
  4. ^ a b Isolation and in vitro antibacterial activity of astilbin, the bioactive flavanone from the leaves of Harungana madagascariensis Lam. ex Poir. (Hypericaceae), B. Moulari, Y. Pellequer, H. Lboutounne, C. Girard, J.-P. Chaumont, J. Millet and F. Muyard,
  5. ^ a b Effects of Astilbe thunbergii rhizomes on wound healing: Part 1. Isolation of promotional effectors from Astilbe thunbergii rhizomes on burn wound healing, Yoshiyuki Kimura, Maho Sumiyoshi and Masahiro Sakanaka, 2006
  6. ^ a b First synthesis of astilbin, biologically active glycosyl flavonoid isolated from Chinese folk medicine, Ken Ohmori, Hiroki Ohrui and Keisuke Suzuki, 2000
  7. ^ a b Identification of a New Metabolite of Astilbin, 3'-O-Methylastilbin, and Its Immunosuppressive Activity against Contact Dermatitis, Jianming Guo, Feng Qian, Jianxin Li, Qiang Xu, Ting Chen, 2006
  8. ^ Isolation, Chemical Identification and Pharmacological Evaluation of Eucryphin, Astilbin and Engelitin Obtained from the Bark of Hymenaea martiana. Eliane Carneiro, João B. Calixto, Franco Delle Monache‌and Rosendo A. Yunes, Pharmaceutical Biology, 1993, Vol. 31, No. 1, Pages 38-46
Flavanonols and their glycosides
3-Hydroxyflavanones:
Ampelopsin (Dihydromyricetin) | Aromadedrin (Dihydrokaempferol) | Dihydrogossypetin | Dihydromorin | Fustin (Dihydrofisetin) | Garbanzol | Taxifolin (Dihydroquercetin)
O-methylated flavanonols
dihydroflavonol 3-O-glycosides
Lecontin | (+)-fustin glucoside
Glycosides
Astilbin | Chrysandroside A | Chrysandroside B | Engeletin | Eucryphin | Smitilbin (Isoastilbin B) | Xeractinol
Acetylated glycosides