| Systematic (IUPAC) name | |
|---|---|
| (11β,16α)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl 2-furoate | |
| Clinical data | |
| AHFS/Drugs.com | monograph |
| Pregnancy cat. | C(US) |
| Legal status | Rx Only (US) |
| Routes | topical, nasal |
| Pharmacokinetic data | |
| Bioavailability | Nasal spray is virtually undetectable in plasma; but systemic availability is comparable to fluticasone.[1] |
| Protein binding | 98% to 99% |
| Metabolism | hepatic |
| Half-life | 5.8 hours |
| Identifiers | |
| CAS number | 105102-22-5 83919-23-7 |
| ATC code | D07AC13 D07XC03, R01AD09, R03BA07 |
| PubChem | CID 441336 |
| DrugBank | APRD00289 |
| ChemSpider | 390091 |
| ChEBI | CHEBI:47564 |
| ChEMBL | CHEMBL1161 |
| Synonyms | (9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate |
| Chemical data | |
| Formula | C22H28Cl2O4 for Mometasone C27H30O6Cl2 as Furoate |
| Mol. mass | 427.361 g/mol (Mometasone) 521.4 g/mol (Furoate) |
| SMILES | eMolecules & PubChem |
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Mometasone furoate (also referred to as mometasone) is a glucocorticosteroid used topically to reduce inflammation of the skin or in the airways.
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Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma[2][3] for patients unresponsive to less potent corticosteroids, and penile phimosis.[4] In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.[5]
It reduces inflammation by causing several effects:[6][7][8]
Schering-Plough markets the medication under the following brand names; Elocon (Elocom, Elomet, Elosalic) as a cream or ointment for skin conditions, Nasonex as a nasal spray for upper respiratory conditions such as nasal sinus inflammation, Asmanex Twisthaler as a dry powder inhaler (DPI) for lower respiratory conditions. Essex pharma markets the medication under the brand name Ecural and Progreś Laboratories markets it under mometAid.
It is also available as a veterinary drug in an otic (ears) form for treatment of otitis externa under the brand name Mometamax.[9]
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